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Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss

Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women. The association between these two diseases are evident through systemic bone loss and alveolar bone loss. Both postmenopausal osteoporosis and periodontitis impose a considerable personal and socioeconomic burden....

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Autores principales: Jayusman, Putri Ayu, Nasruddin, Nurrul Shaqinah, Baharin, Badiah, Ibrahim, Nurul ‘Izzah, Ahmad Hairi, Haryati, Shuid, Ahmad Nazrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995413/
https://www.ncbi.nlm.nih.gov/pubmed/36909165
http://dx.doi.org/10.3389/fphar.2023.1120457
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author Jayusman, Putri Ayu
Nasruddin, Nurrul Shaqinah
Baharin, Badiah
Ibrahim, Nurul ‘Izzah
Ahmad Hairi, Haryati
Shuid, Ahmad Nazrun
author_facet Jayusman, Putri Ayu
Nasruddin, Nurrul Shaqinah
Baharin, Badiah
Ibrahim, Nurul ‘Izzah
Ahmad Hairi, Haryati
Shuid, Ahmad Nazrun
author_sort Jayusman, Putri Ayu
collection PubMed
description Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women. The association between these two diseases are evident through systemic bone loss and alveolar bone loss. Both postmenopausal osteoporosis and periodontitis impose a considerable personal and socioeconomic burden. Biphosphonate and hormone replacement therapy are effective in preventing bone loss in postmenopausal osteoporosis and periodontitis, but they are coupled with severe adverse effects. Phytoestrogens are plant-based estrogen-like compounds, which have been used for the treatment of menopause-related symptoms. In the last decades, numerous preclinical and clinical studies have been carried out to evaluate the therapeutic effects of phytoestrogens including bone health. The aim of this article is to give an overview of the bidirectional interrelationship between postmenopausal osteoporosis and periodontitis, summarize the skeletal effects of phytoestrogens and report the most studied phytoestrogens with promising alveolar bone protective effect in postmenopausal osteoporosis model, with and without experimental periodontitis. To date, there are limited studies on the effects of phytoestrogens on alveolar bone in postmenopausal osteoporosis. Phytoestrogens may have exerted their bone protective effect by inhibiting bone resorption and enhancing bone formation. With the reported findings on the protective effects of phytoestrogens on bone, well-designed trials are needed to better investigate their therapeutic effects. The compilation of outcomes presented in this review may provide an overview of the recent research findings in this field and direct further in vivo and clinical studies in the future.
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spelling pubmed-99954132023-03-10 Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss Jayusman, Putri Ayu Nasruddin, Nurrul Shaqinah Baharin, Badiah Ibrahim, Nurul ‘Izzah Ahmad Hairi, Haryati Shuid, Ahmad Nazrun Front Pharmacol Pharmacology Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women. The association between these two diseases are evident through systemic bone loss and alveolar bone loss. Both postmenopausal osteoporosis and periodontitis impose a considerable personal and socioeconomic burden. Biphosphonate and hormone replacement therapy are effective in preventing bone loss in postmenopausal osteoporosis and periodontitis, but they are coupled with severe adverse effects. Phytoestrogens are plant-based estrogen-like compounds, which have been used for the treatment of menopause-related symptoms. In the last decades, numerous preclinical and clinical studies have been carried out to evaluate the therapeutic effects of phytoestrogens including bone health. The aim of this article is to give an overview of the bidirectional interrelationship between postmenopausal osteoporosis and periodontitis, summarize the skeletal effects of phytoestrogens and report the most studied phytoestrogens with promising alveolar bone protective effect in postmenopausal osteoporosis model, with and without experimental periodontitis. To date, there are limited studies on the effects of phytoestrogens on alveolar bone in postmenopausal osteoporosis. Phytoestrogens may have exerted their bone protective effect by inhibiting bone resorption and enhancing bone formation. With the reported findings on the protective effects of phytoestrogens on bone, well-designed trials are needed to better investigate their therapeutic effects. The compilation of outcomes presented in this review may provide an overview of the recent research findings in this field and direct further in vivo and clinical studies in the future. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995413/ /pubmed/36909165 http://dx.doi.org/10.3389/fphar.2023.1120457 Text en Copyright © 2023 Jayusman, Nasruddin, Baharin, Ibrahim, Ahmad Hairi and Shuid. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jayusman, Putri Ayu
Nasruddin, Nurrul Shaqinah
Baharin, Badiah
Ibrahim, Nurul ‘Izzah
Ahmad Hairi, Haryati
Shuid, Ahmad Nazrun
Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title_full Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title_fullStr Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title_full_unstemmed Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title_short Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss
title_sort overview on postmenopausal osteoporosis and periodontitis: the therapeutic potential of phytoestrogens against alveolar bone loss
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995413/
https://www.ncbi.nlm.nih.gov/pubmed/36909165
http://dx.doi.org/10.3389/fphar.2023.1120457
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