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Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers

This study aims to estimate the association between some heavy metals in suspended particulate matter (SPM) and kidney damage among workers at different departments in a secondary aluminum production plant. It also investigates the association between Xeroderma Pigmentosum complementation group D (X...

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Autores principales: Moubarz, Gehan, Mohammed, Atef M. F., Saleh, Inas A., Shahy, Eman M., Helmy, Mona A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995418/
https://www.ncbi.nlm.nih.gov/pubmed/36418822
http://dx.doi.org/10.1007/s11356-022-24270-4
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author Moubarz, Gehan
Mohammed, Atef M. F.
Saleh, Inas A.
Shahy, Eman M.
Helmy, Mona A.
author_facet Moubarz, Gehan
Mohammed, Atef M. F.
Saleh, Inas A.
Shahy, Eman M.
Helmy, Mona A.
author_sort Moubarz, Gehan
collection PubMed
description This study aims to estimate the association between some heavy metals in suspended particulate matter (SPM) and kidney damage among workers at different departments in a secondary aluminum production plant. It also investigates the association between Xeroderma Pigmentosum complementation group D (XPD) gene polymorphisms and worker’s susceptibility to kidney dysfunction. It was conducted on 30 workers from the administrative departments and 147 workers from different departments in the production line. Estimation of some heavy metals (Al, Co, Ni, Cu, Pb, and Cd) in suspended particulate matter (SPM) is done. Also, urinary levels of those metals were measured for all workers. Kidney injury molecule 1 (KIM-1), clusterin levels, and XPD protein level were estimated. Genotyping of XPD gene polymorphisms was performed. The measured annual average concentrations of the estimated heavy metals were lower than the permissible limits. Gravity area had the maximum concentration of metals with a higher Al average daily dose and hazardous index > 1. Kidney injury biomarkers (clusterin and KIM-1) were increased significantly (p < 0.05) while XPD protein showed the lowest levels among workers at the gravity and cold rolling areas. XPD Asn/Asp genotype was more dominant among those workers (85.7%). Conclusion: aluminum workers are at risk of kidney disorders due to heavy metal exposure. The individual’s susceptibility to the diseases is related to the DNA repair efficiency mechanisms. The defect in XPD protein represents a good indicator of susceptibility to the disease. KIM-1 and clusterin estimation is a predictor biomarker for early-staged kidney diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-24270-4.
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spelling pubmed-99954182023-03-10 Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers Moubarz, Gehan Mohammed, Atef M. F. Saleh, Inas A. Shahy, Eman M. Helmy, Mona A. Environ Sci Pollut Res Int Research Article This study aims to estimate the association between some heavy metals in suspended particulate matter (SPM) and kidney damage among workers at different departments in a secondary aluminum production plant. It also investigates the association between Xeroderma Pigmentosum complementation group D (XPD) gene polymorphisms and worker’s susceptibility to kidney dysfunction. It was conducted on 30 workers from the administrative departments and 147 workers from different departments in the production line. Estimation of some heavy metals (Al, Co, Ni, Cu, Pb, and Cd) in suspended particulate matter (SPM) is done. Also, urinary levels of those metals were measured for all workers. Kidney injury molecule 1 (KIM-1), clusterin levels, and XPD protein level were estimated. Genotyping of XPD gene polymorphisms was performed. The measured annual average concentrations of the estimated heavy metals were lower than the permissible limits. Gravity area had the maximum concentration of metals with a higher Al average daily dose and hazardous index > 1. Kidney injury biomarkers (clusterin and KIM-1) were increased significantly (p < 0.05) while XPD protein showed the lowest levels among workers at the gravity and cold rolling areas. XPD Asn/Asp genotype was more dominant among those workers (85.7%). Conclusion: aluminum workers are at risk of kidney disorders due to heavy metal exposure. The individual’s susceptibility to the diseases is related to the DNA repair efficiency mechanisms. The defect in XPD protein represents a good indicator of susceptibility to the disease. KIM-1 and clusterin estimation is a predictor biomarker for early-staged kidney diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-24270-4. Springer Berlin Heidelberg 2022-11-23 2023 /pmc/articles/PMC9995418/ /pubmed/36418822 http://dx.doi.org/10.1007/s11356-022-24270-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Moubarz, Gehan
Mohammed, Atef M. F.
Saleh, Inas A.
Shahy, Eman M.
Helmy, Mona A.
Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title_full Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title_fullStr Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title_full_unstemmed Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title_short Nephrotoxic effect of heavy metals and the role of DNA repair gene among secondary aluminum smelter workers
title_sort nephrotoxic effect of heavy metals and the role of dna repair gene among secondary aluminum smelter workers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995418/
https://www.ncbi.nlm.nih.gov/pubmed/36418822
http://dx.doi.org/10.1007/s11356-022-24270-4
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