Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling

Dominant mutations in tyrosyl-tRNA synthetase (YARS1) and six other tRNA ligases cause Charcot-Marie-Tooth peripheral neuropathy (CMT). Loss of aminoacylation is not required for their pathogenicity, suggesting a gain-of-function disease mechanism. By an unbiased genetic screen in Drosophila, we lin...

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Detalles Bibliográficos
Autores principales: Ermanoska, Biljana, Asselbergh, Bob, Morant, Laura, Petrovic-Erfurth, Maria-Luise, Hosseinibarkooie, Seyyedmohsen, Leitão-Gonçalves, Ricardo, Almeida-Souza, Leonardo, Bervoets, Sven, Sun, Litao, Lee, LaTasha, Atkinson, Derek, Khanghahi, Akram, Tournev, Ivaylo, Callaerts, Patrick, Verstreken, Patrik, Yang, Xiang-Lei, Wirth, Brunhilde, Rodal, Avital A., Timmerman, Vincent, Goode, Bruce L., Godenschwege, Tanja A., Jordanova, Albena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995517/
https://www.ncbi.nlm.nih.gov/pubmed/36890170
http://dx.doi.org/10.1038/s41467-023-35908-3

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