Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestrating the response to long-term pharmacologically induced Acly inhibition are unknown. We repor...

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Detalles Bibliográficos
Autores principales: Sola-García, Alejandro, Cáliz-Molina, María Ángeles, Espadas, Isabel, Petr, Michael, Panadero-Morón, Concepción, González-Morán, Daniel, Martín-Vázquez, María Eugenia, Narbona-Pérez, Álvaro Jesús, López-Noriega, Livia, Martínez-Corrales, Guillermo, López-Fernández-Sobrino, Raúl, Carmona-Marin, Lina M., Martínez-Force, Enrique, Yanes, Oscar, Vinaixa, Maria, López-López, Daniel, Reyes, José Carlos, Dopazo, Joaquín, Martín, Franz, Gauthier, Benoit R., Scheibye-Knudsen, Morten, Capilla-González, Vivian, Martín-Montalvo, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995519/
https://www.ncbi.nlm.nih.gov/pubmed/36890357
http://dx.doi.org/10.1038/s42003-023-04625-4

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