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Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study
BACKGROUND: We aimed to evaluate the current status of first-line treatment options for prostate cancer in patients aged ≥75 years in Korea. MATERIALS AND METHODS: The study included 873 patients diagnosed with biopsy-proven prostate cancer at 5 institutions in Korea from January 2009 to December 20...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Pacific Prostate Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995689/ https://www.ncbi.nlm.nih.gov/pubmed/36910903 http://dx.doi.org/10.1016/j.prnil.2022.08.003 |
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author | Park, Dong Jin Kang, Ho Won Kwon, Se Yun Seo, Young Jin Lee, Kyung Seop Kim, Byung Hoon Shin, Teak Jun Kim, Won Tae Kim, Yong-June Yun, Seok Joong Lee, Sang-Cheol Chung, Jae-Wook Choi, Seock Hwan Lee, Jun Nyung Kim, Hyun Tae Kim, Tae-Hwan Yoo, Eun Sang Kwon, Tae Gyun Jung, Wonho Ha, Yun-Sok |
author_facet | Park, Dong Jin Kang, Ho Won Kwon, Se Yun Seo, Young Jin Lee, Kyung Seop Kim, Byung Hoon Shin, Teak Jun Kim, Won Tae Kim, Yong-June Yun, Seok Joong Lee, Sang-Cheol Chung, Jae-Wook Choi, Seock Hwan Lee, Jun Nyung Kim, Hyun Tae Kim, Tae-Hwan Yoo, Eun Sang Kwon, Tae Gyun Jung, Wonho Ha, Yun-Sok |
author_sort | Park, Dong Jin |
collection | PubMed |
description | BACKGROUND: We aimed to evaluate the current status of first-line treatment options for prostate cancer in patients aged ≥75 years in Korea. MATERIALS AND METHODS: The study included 873 patients diagnosed with biopsy-proven prostate cancer at 5 institutions in Korea from January 2009 to December 2018. Inclusion criteria were aged ≥75 years at diagnosis, prostate biopsy with ≥12 cores, and follow-up period ≥1 year. Clinical data were retrospectively collected from electronic medical records. RESULTS: Primary treatment for prostate cancer in patients aged ≥75 years included androgen deprivation therapy (ADT) (n = 614), radical prostatectomy (RP) (n = 114), and radiation therapy (n = 62). Among patients with RP, nine patients received ADT before RP. The RP group was younger with better Eastern Cooperative Oncology Group Performance Status (ECOG PS), lower initial prostate-specific antigen (PSA), Gleason score (GS), max percent positive cores, less positive cores, and less advanced clinical Tumor Node Metastasis (TNM) stage compared with the ADT group. Multivariate analysis showed that age, ECOG PS, and PSA were independent prognostic factors for RP. When the ADT group was classified by therapeutic regimens, the most common therapeutic regimen was maximal androgen blockade (MAB) (n = 571), and leuprolide + bicalutamide (n = 330) was the most common MAB regimen. Multivariate analysis for secondary treatment showed that age, ECOG PS, GS, and clinical N1 or M1 stage were independent predictive factors. Enzalutamide was the most preferred treatment for tertiary treatment. CONCLUSION: In patients with prostate cancer aged ≥75 years, the most common treatment option was MAB, and the leuprolide + bicalutamide was the most common MAB regimen. Age, ECOG PS, and PSA are the useful indicators of surgical treatment, which increased during the study period. Younger patients with high GS and advanced clinical stage were more likely to undergo secondary treatment. |
format | Online Article Text |
id | pubmed-9995689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Asian Pacific Prostate Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99956892023-03-10 Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study Park, Dong Jin Kang, Ho Won Kwon, Se Yun Seo, Young Jin Lee, Kyung Seop Kim, Byung Hoon Shin, Teak Jun Kim, Won Tae Kim, Yong-June Yun, Seok Joong Lee, Sang-Cheol Chung, Jae-Wook Choi, Seock Hwan Lee, Jun Nyung Kim, Hyun Tae Kim, Tae-Hwan Yoo, Eun Sang Kwon, Tae Gyun Jung, Wonho Ha, Yun-Sok Prostate Int Research Article BACKGROUND: We aimed to evaluate the current status of first-line treatment options for prostate cancer in patients aged ≥75 years in Korea. MATERIALS AND METHODS: The study included 873 patients diagnosed with biopsy-proven prostate cancer at 5 institutions in Korea from January 2009 to December 2018. Inclusion criteria were aged ≥75 years at diagnosis, prostate biopsy with ≥12 cores, and follow-up period ≥1 year. Clinical data were retrospectively collected from electronic medical records. RESULTS: Primary treatment for prostate cancer in patients aged ≥75 years included androgen deprivation therapy (ADT) (n = 614), radical prostatectomy (RP) (n = 114), and radiation therapy (n = 62). Among patients with RP, nine patients received ADT before RP. The RP group was younger with better Eastern Cooperative Oncology Group Performance Status (ECOG PS), lower initial prostate-specific antigen (PSA), Gleason score (GS), max percent positive cores, less positive cores, and less advanced clinical Tumor Node Metastasis (TNM) stage compared with the ADT group. Multivariate analysis showed that age, ECOG PS, and PSA were independent prognostic factors for RP. When the ADT group was classified by therapeutic regimens, the most common therapeutic regimen was maximal androgen blockade (MAB) (n = 571), and leuprolide + bicalutamide (n = 330) was the most common MAB regimen. Multivariate analysis for secondary treatment showed that age, ECOG PS, GS, and clinical N1 or M1 stage were independent predictive factors. Enzalutamide was the most preferred treatment for tertiary treatment. CONCLUSION: In patients with prostate cancer aged ≥75 years, the most common treatment option was MAB, and the leuprolide + bicalutamide was the most common MAB regimen. Age, ECOG PS, and PSA are the useful indicators of surgical treatment, which increased during the study period. Younger patients with high GS and advanced clinical stage were more likely to undergo secondary treatment. Asian Pacific Prostate Society 2023-03 2022-08-29 /pmc/articles/PMC9995689/ /pubmed/36910903 http://dx.doi.org/10.1016/j.prnil.2022.08.003 Text en © 2022 Asian Pacific Prostate Society. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Park, Dong Jin Kang, Ho Won Kwon, Se Yun Seo, Young Jin Lee, Kyung Seop Kim, Byung Hoon Shin, Teak Jun Kim, Won Tae Kim, Yong-June Yun, Seok Joong Lee, Sang-Cheol Chung, Jae-Wook Choi, Seock Hwan Lee, Jun Nyung Kim, Hyun Tae Kim, Tae-Hwan Yoo, Eun Sang Kwon, Tae Gyun Jung, Wonho Ha, Yun-Sok Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title | Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title_full | Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title_fullStr | Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title_full_unstemmed | Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title_short | Current treatment patterns within 1 year after prostate cancer diagnosis in Korean patients over 75 years old: a retrospective multicenter study |
title_sort | current treatment patterns within 1 year after prostate cancer diagnosis in korean patients over 75 years old: a retrospective multicenter study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995689/ https://www.ncbi.nlm.nih.gov/pubmed/36910903 http://dx.doi.org/10.1016/j.prnil.2022.08.003 |
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