The potential roles of galectin-3 in AKI and CKD

Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated...

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Autores principales: Wang, Fengyun, Zhou, Lixin, Eliaz, Amity, Hu, Chang, Qiang, Xinhua, Ke, Li, Chertow, Glenn, Eliaz, Isaac, Peng, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995706/
https://www.ncbi.nlm.nih.gov/pubmed/36909244
http://dx.doi.org/10.3389/fphys.2023.1090724
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author Wang, Fengyun
Zhou, Lixin
Eliaz, Amity
Hu, Chang
Qiang, Xinhua
Ke, Li
Chertow, Glenn
Eliaz, Isaac
Peng, Zhiyong
author_facet Wang, Fengyun
Zhou, Lixin
Eliaz, Amity
Hu, Chang
Qiang, Xinhua
Ke, Li
Chertow, Glenn
Eliaz, Isaac
Peng, Zhiyong
author_sort Wang, Fengyun
collection PubMed
description Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated in the development of both AKI and CKD. Serum Gal3 levels are elevated in patients with AKI and CKD, and elevated Gal3 is associated with progression of CKD. In addition, Gal3 is associated with the incidence of AKI among critically ill patients, and blocking Gal3 in murine models of sepsis and ischemia-reperfusion injury results in significantly lower AKI incidence and mortality. Here we review the role of Gal3 in the pathophysiology of AKI and CKD, as well as the therapeutic potential of targeting Gal3.
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spelling pubmed-99957062023-03-10 The potential roles of galectin-3 in AKI and CKD Wang, Fengyun Zhou, Lixin Eliaz, Amity Hu, Chang Qiang, Xinhua Ke, Li Chertow, Glenn Eliaz, Isaac Peng, Zhiyong Front Physiol Physiology Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated in the development of both AKI and CKD. Serum Gal3 levels are elevated in patients with AKI and CKD, and elevated Gal3 is associated with progression of CKD. In addition, Gal3 is associated with the incidence of AKI among critically ill patients, and blocking Gal3 in murine models of sepsis and ischemia-reperfusion injury results in significantly lower AKI incidence and mortality. Here we review the role of Gal3 in the pathophysiology of AKI and CKD, as well as the therapeutic potential of targeting Gal3. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995706/ /pubmed/36909244 http://dx.doi.org/10.3389/fphys.2023.1090724 Text en Copyright © 2023 Wang, Zhou, Eliaz, Hu, Qiang, Ke, Chertow, Eliaz and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Fengyun
Zhou, Lixin
Eliaz, Amity
Hu, Chang
Qiang, Xinhua
Ke, Li
Chertow, Glenn
Eliaz, Isaac
Peng, Zhiyong
The potential roles of galectin-3 in AKI and CKD
title The potential roles of galectin-3 in AKI and CKD
title_full The potential roles of galectin-3 in AKI and CKD
title_fullStr The potential roles of galectin-3 in AKI and CKD
title_full_unstemmed The potential roles of galectin-3 in AKI and CKD
title_short The potential roles of galectin-3 in AKI and CKD
title_sort potential roles of galectin-3 in aki and ckd
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995706/
https://www.ncbi.nlm.nih.gov/pubmed/36909244
http://dx.doi.org/10.3389/fphys.2023.1090724
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