Cargando…
Locomotor learning in infants at high risk for cerebral palsy: A study protocol
BACKGROUND: Physical disability in individuals with cerebral palsy (CP) creates lifelong mobility challenges and healthcare costs. Despite this, very little is known about how infants at high risk for CP learn to move and acquire early locomotor skills, which set the foundation for lifelong mobility...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995839/ https://www.ncbi.nlm.nih.gov/pubmed/36911033 http://dx.doi.org/10.3389/fped.2023.891633 |
_version_ | 1784902907363065856 |
---|---|
author | Prosser, Laura A. Skorup, Julie Pierce, Samuel R. Jawad, Abbas F. Fagg, Andrew H. Kolobe, Thubi H. A. Smith, Beth A. |
author_facet | Prosser, Laura A. Skorup, Julie Pierce, Samuel R. Jawad, Abbas F. Fagg, Andrew H. Kolobe, Thubi H. A. Smith, Beth A. |
author_sort | Prosser, Laura A. |
collection | PubMed |
description | BACKGROUND: Physical disability in individuals with cerebral palsy (CP) creates lifelong mobility challenges and healthcare costs. Despite this, very little is known about how infants at high risk for CP learn to move and acquire early locomotor skills, which set the foundation for lifelong mobility. The objective of this project is to characterize the evolution of locomotor learning over the first 18 months of life in infants at high risk for CP. To characterize how locomotor skill is learned, we will use robotic and sensor technology to provide intervention and longitudinally study infant movement across three stages of the development of human motor control: early spontaneous movement, prone locomotion (crawling), and upright locomotion (walking). STUDY DESIGN: This longitudinal observational/intervention cohort study (ClinicalTrials.gov Identifier: NCT04561232) will enroll sixty participants who are at risk for CP due to a brain injury by one month post-term age. Study participation will be completed by 18 months of age. Early spontaneous leg movements will be measured monthly from 1 to 4 months of age using inertial sensors worn on the ankles for two full days each month. Infants who remain at high risk for CP at 4 months of age, as determined from clinical assessments of motor function and movement quality, will continue through two locomotor training phases. Prone locomotor training will be delivered from 5 to 9 months of age using a robotic crawl training device that responds to infant behavior in real-time. Upright locomotor training will be delivered from 9 to 18 months of age using a dynamic weight support system to allow participants to practice skills beyond their current level of function. Repeated assessments of locomotor skill, training characteristics (such as movement error, variability, movement time and postural control), and variables that may mediate locomotor learning will be collected every two months during prone training and every three months during upright training. DISCUSSION: This study will develop predictive models of locomotor skill acquisition over time. We hypothesize that experiencing and correcting movement errors is critical to skill acquisition in infants at risk for CP and that locomotor learning is mediated by neurobehavioral factors outside of training. Project Number 1R01HD098364-01A1. ClinicalTrials.gov Identifier: NCT04561232 |
format | Online Article Text |
id | pubmed-9995839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99958392023-03-10 Locomotor learning in infants at high risk for cerebral palsy: A study protocol Prosser, Laura A. Skorup, Julie Pierce, Samuel R. Jawad, Abbas F. Fagg, Andrew H. Kolobe, Thubi H. A. Smith, Beth A. Front Pediatr Pediatrics BACKGROUND: Physical disability in individuals with cerebral palsy (CP) creates lifelong mobility challenges and healthcare costs. Despite this, very little is known about how infants at high risk for CP learn to move and acquire early locomotor skills, which set the foundation for lifelong mobility. The objective of this project is to characterize the evolution of locomotor learning over the first 18 months of life in infants at high risk for CP. To characterize how locomotor skill is learned, we will use robotic and sensor technology to provide intervention and longitudinally study infant movement across three stages of the development of human motor control: early spontaneous movement, prone locomotion (crawling), and upright locomotion (walking). STUDY DESIGN: This longitudinal observational/intervention cohort study (ClinicalTrials.gov Identifier: NCT04561232) will enroll sixty participants who are at risk for CP due to a brain injury by one month post-term age. Study participation will be completed by 18 months of age. Early spontaneous leg movements will be measured monthly from 1 to 4 months of age using inertial sensors worn on the ankles for two full days each month. Infants who remain at high risk for CP at 4 months of age, as determined from clinical assessments of motor function and movement quality, will continue through two locomotor training phases. Prone locomotor training will be delivered from 5 to 9 months of age using a robotic crawl training device that responds to infant behavior in real-time. Upright locomotor training will be delivered from 9 to 18 months of age using a dynamic weight support system to allow participants to practice skills beyond their current level of function. Repeated assessments of locomotor skill, training characteristics (such as movement error, variability, movement time and postural control), and variables that may mediate locomotor learning will be collected every two months during prone training and every three months during upright training. DISCUSSION: This study will develop predictive models of locomotor skill acquisition over time. We hypothesize that experiencing and correcting movement errors is critical to skill acquisition in infants at risk for CP and that locomotor learning is mediated by neurobehavioral factors outside of training. Project Number 1R01HD098364-01A1. ClinicalTrials.gov Identifier: NCT04561232 Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995839/ /pubmed/36911033 http://dx.doi.org/10.3389/fped.2023.891633 Text en © 2023 Prosser, Skorup, Pierce, Jawad, Fagg, Kolobe and Smith. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Prosser, Laura A. Skorup, Julie Pierce, Samuel R. Jawad, Abbas F. Fagg, Andrew H. Kolobe, Thubi H. A. Smith, Beth A. Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title | Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title_full | Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title_fullStr | Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title_full_unstemmed | Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title_short | Locomotor learning in infants at high risk for cerebral palsy: A study protocol |
title_sort | locomotor learning in infants at high risk for cerebral palsy: a study protocol |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995839/ https://www.ncbi.nlm.nih.gov/pubmed/36911033 http://dx.doi.org/10.3389/fped.2023.891633 |
work_keys_str_mv | AT prosserlauraa locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT skorupjulie locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT piercesamuelr locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT jawadabbasf locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT faggandrewh locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT kolobethubiha locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol AT smithbetha locomotorlearningininfantsathighriskforcerebralpalsyastudyprotocol |