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Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry
OBJECTIVE: To describe the incidence and survival outcomes of uterine cervical cancer during 1999–2018. METHODS: Patients who were diagnosed with cervical cancer during 1999–2018 were identified in the Korea Central Cancer Registry. Age-standardized incidence rates (ASRs) and annual percent changes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995866/ https://www.ncbi.nlm.nih.gov/pubmed/36731896 http://dx.doi.org/10.3802/jgo.2023.34.e39 |
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author | Suh, Dong Hoon Ha, Hyeong In Lee, Yeon Jee Lim, Jiwon Won, Young-Joo Lim, Myong Cheol |
author_facet | Suh, Dong Hoon Ha, Hyeong In Lee, Yeon Jee Lim, Jiwon Won, Young-Joo Lim, Myong Cheol |
author_sort | Suh, Dong Hoon |
collection | PubMed |
description | OBJECTIVE: To describe the incidence and survival outcomes of uterine cervical cancer during 1999–2018. METHODS: Patients who were diagnosed with cervical cancer during 1999–2018 were identified in the Korea Central Cancer Registry. Age-standardized incidence rates (ASRs) and annual percent changes (APCs) were calculated. Survival rates by histology, year of diagnosis (1999–2008 vs. 2009–2018), stage, and age at diagnosis were analyzed. RESULTS: The absolute incidence of cervical cancer decreased over 20 years from 4,488 in 1999 to 3,500 in 2018, with an APC of −3.42% (p<0.0001). While ASR of squamous cell carcinoma (SCCA) more than halved from 13.27 per 100,000 in 1999 to 6.16 in 2018 (APC, −4.04%), adenocarcinoma continued to rise (ASR, 1.30 per 100,000 to 1.92; APC, 1.52%; p<0.0001). Patients with adenocarcinoma were younger than those with SCCA (mean, 49.9±12.7 vs. 52.9 ±14.6 years; p<0.0001). Five-year survival rate of cervical cancer patients overall was 78.0%. Adenocarcinoma had poorer survival than SCCA (5-year survival rate, 76.8% vs. 79.8%; p<0.0001). There was no survival difference between patients who were diagnosed between 1999–2008 and 2009–2018. Earlier-stage disease had better survival (5-year survival rate for localized, regional, and distant disease, 90.0% vs. 69.9% vs. 26.5%; p<0.0001). Younger patients aged <50 years had better survival than those aged ≥50 years (87.1% vs. 69.8%; p<0.0001). CONCLUSION: The incidence of SCCA of the uterine cervix declined while adenocarcinoma continued to increase slowly but significantly from 1999 to 2018 in Korea. Adenocarcinoma was diagnosed at a younger age, but had poorer survival outcome than SCCA. |
format | Online Article Text |
id | pubmed-9995866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-99958662023-03-10 Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry Suh, Dong Hoon Ha, Hyeong In Lee, Yeon Jee Lim, Jiwon Won, Young-Joo Lim, Myong Cheol J Gynecol Oncol Original Article OBJECTIVE: To describe the incidence and survival outcomes of uterine cervical cancer during 1999–2018. METHODS: Patients who were diagnosed with cervical cancer during 1999–2018 were identified in the Korea Central Cancer Registry. Age-standardized incidence rates (ASRs) and annual percent changes (APCs) were calculated. Survival rates by histology, year of diagnosis (1999–2008 vs. 2009–2018), stage, and age at diagnosis were analyzed. RESULTS: The absolute incidence of cervical cancer decreased over 20 years from 4,488 in 1999 to 3,500 in 2018, with an APC of −3.42% (p<0.0001). While ASR of squamous cell carcinoma (SCCA) more than halved from 13.27 per 100,000 in 1999 to 6.16 in 2018 (APC, −4.04%), adenocarcinoma continued to rise (ASR, 1.30 per 100,000 to 1.92; APC, 1.52%; p<0.0001). Patients with adenocarcinoma were younger than those with SCCA (mean, 49.9±12.7 vs. 52.9 ±14.6 years; p<0.0001). Five-year survival rate of cervical cancer patients overall was 78.0%. Adenocarcinoma had poorer survival than SCCA (5-year survival rate, 76.8% vs. 79.8%; p<0.0001). There was no survival difference between patients who were diagnosed between 1999–2008 and 2009–2018. Earlier-stage disease had better survival (5-year survival rate for localized, regional, and distant disease, 90.0% vs. 69.9% vs. 26.5%; p<0.0001). Younger patients aged <50 years had better survival than those aged ≥50 years (87.1% vs. 69.8%; p<0.0001). CONCLUSION: The incidence of SCCA of the uterine cervix declined while adenocarcinoma continued to increase slowly but significantly from 1999 to 2018 in Korea. Adenocarcinoma was diagnosed at a younger age, but had poorer survival outcome than SCCA. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2023-01-19 /pmc/articles/PMC9995866/ /pubmed/36731896 http://dx.doi.org/10.3802/jgo.2023.34.e39 Text en © 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Suh, Dong Hoon Ha, Hyeong In Lee, Yeon Jee Lim, Jiwon Won, Young-Joo Lim, Myong Cheol Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title | Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title_full | Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title_fullStr | Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title_full_unstemmed | Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title_short | Incidence and treatment outcomes of uterine cervical cancer in Korea 1999–2018 from the national cancer registry |
title_sort | incidence and treatment outcomes of uterine cervical cancer in korea 1999–2018 from the national cancer registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995866/ https://www.ncbi.nlm.nih.gov/pubmed/36731896 http://dx.doi.org/10.3802/jgo.2023.34.e39 |
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