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A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer

MAIN POINT: Our retrospective analysis of a large number of cases found in patients with primary colorectal cancer (CRC) carrying positive HBsAg inhibited the occurrence of synchronous liver metastases (SLM). However, liver cirrhosis caused by non-HBV factors promoted the occurrence of SLM. OBJECTIV...

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Autores principales: Zhu, Lin, Gong, Piqing, Liu, Ye, Shi, Yunjie, Wang, Wenqiang, Zhang, Wei, Hu, Zhiqian, Li, Xinxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995980/
https://www.ncbi.nlm.nih.gov/pubmed/36910607
http://dx.doi.org/10.3389/fonc.2023.1109464
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author Zhu, Lin
Gong, Piqing
Liu, Ye
Shi, Yunjie
Wang, Wenqiang
Zhang, Wei
Hu, Zhiqian
Li, Xinxing
author_facet Zhu, Lin
Gong, Piqing
Liu, Ye
Shi, Yunjie
Wang, Wenqiang
Zhang, Wei
Hu, Zhiqian
Li, Xinxing
author_sort Zhu, Lin
collection PubMed
description MAIN POINT: Our retrospective analysis of a large number of cases found in patients with primary colorectal cancer (CRC) carrying positive HBsAg inhibited the occurrence of synchronous liver metastases (SLM). However, liver cirrhosis caused by non-HBV factors promoted the occurrence of SLM. OBJECTIVES: This study aimed to investigate the effect of HBV on the occurrence of synchronous liver metastases (SLM) of colorectal cancer (CRC). METHODS: Univariate and multivariate analyses were used to analyze the influence of clinical parameters on the occurrence of SLM. RESULTS: A total of 6, 020 patients with primary CRC were included in our study, of which 449 patients carrying HBsAg(+) accounted for 7.46%. 44 cases of SLM occurred in the HBsAg(+) group, accounting for 9.80%, which was much lower than 13.6% (758/5571) in the HBsAg(-) group (X=5.214, P=0.022). Among CRC patients with HBsAg(-), the incidence of SLM was 24.9% and 14.9% in the group with high APRI and FIB-4 levels, respectively, which were significantly higher than that in the compared groups (12.3% and 12.5%, all P<0.05). Compared with the control group, female patients, late-onset patients, and HBV-infective patients had lower risks of SLM (HR=0.737, 95%CI: 0.614-0.883, P<0.001; HR=0.752, 95%CI: 0.603-0.943, P=0.013; HR=0.682, 95%CI: 0.473-0.961, P=0.034). CONCLUSIONS: The carriage of HBsAg(+) status inhibited the occurrence of SLM from CRC. HBV-causing liver cirrhosis did not further influence the occurrence of SLM, whereas non-HBV-factor cirrhosis promoted the occurrence of SLM. Nevertheless, this still required prospective data validation.
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spelling pubmed-99959802023-03-10 A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer Zhu, Lin Gong, Piqing Liu, Ye Shi, Yunjie Wang, Wenqiang Zhang, Wei Hu, Zhiqian Li, Xinxing Front Oncol Oncology MAIN POINT: Our retrospective analysis of a large number of cases found in patients with primary colorectal cancer (CRC) carrying positive HBsAg inhibited the occurrence of synchronous liver metastases (SLM). However, liver cirrhosis caused by non-HBV factors promoted the occurrence of SLM. OBJECTIVES: This study aimed to investigate the effect of HBV on the occurrence of synchronous liver metastases (SLM) of colorectal cancer (CRC). METHODS: Univariate and multivariate analyses were used to analyze the influence of clinical parameters on the occurrence of SLM. RESULTS: A total of 6, 020 patients with primary CRC were included in our study, of which 449 patients carrying HBsAg(+) accounted for 7.46%. 44 cases of SLM occurred in the HBsAg(+) group, accounting for 9.80%, which was much lower than 13.6% (758/5571) in the HBsAg(-) group (X=5.214, P=0.022). Among CRC patients with HBsAg(-), the incidence of SLM was 24.9% and 14.9% in the group with high APRI and FIB-4 levels, respectively, which were significantly higher than that in the compared groups (12.3% and 12.5%, all P<0.05). Compared with the control group, female patients, late-onset patients, and HBV-infective patients had lower risks of SLM (HR=0.737, 95%CI: 0.614-0.883, P<0.001; HR=0.752, 95%CI: 0.603-0.943, P=0.013; HR=0.682, 95%CI: 0.473-0.961, P=0.034). CONCLUSIONS: The carriage of HBsAg(+) status inhibited the occurrence of SLM from CRC. HBV-causing liver cirrhosis did not further influence the occurrence of SLM, whereas non-HBV-factor cirrhosis promoted the occurrence of SLM. Nevertheless, this still required prospective data validation. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9995980/ /pubmed/36910607 http://dx.doi.org/10.3389/fonc.2023.1109464 Text en Copyright © 2023 Zhu, Gong, Liu, Shi, Wang, Zhang, Hu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhu, Lin
Gong, Piqing
Liu, Ye
Shi, Yunjie
Wang, Wenqiang
Zhang, Wei
Hu, Zhiqian
Li, Xinxing
A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title_full A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title_fullStr A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title_full_unstemmed A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title_short A retrospective case-series of influence of chronic hepatitis B on synchronous liver metastasis of colorectal cancer
title_sort retrospective case-series of influence of chronic hepatitis b on synchronous liver metastasis of colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995980/
https://www.ncbi.nlm.nih.gov/pubmed/36910607
http://dx.doi.org/10.3389/fonc.2023.1109464
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