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Human CD8(+) T-Cell Populations That Express Natural Killer Receptors

CD8(+) T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8(+) T cells and NK cells play distinct ro...

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Autores principales: Koh, June-Young, Kim, Dong-Uk, Moon, Bae-Hyeon, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995994/
https://www.ncbi.nlm.nih.gov/pubmed/36911797
http://dx.doi.org/10.4110/in.2023.23.e8
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author Koh, June-Young
Kim, Dong-Uk
Moon, Bae-Hyeon
Shin, Eui-Cheol
author_facet Koh, June-Young
Kim, Dong-Uk
Moon, Bae-Hyeon
Shin, Eui-Cheol
author_sort Koh, June-Young
collection PubMed
description CD8(+) T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8(+) T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8(+) T cells have been found to express activating or inhibitory NK receptors. CD8(+) T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8(+) T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8(+) T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations.
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spelling pubmed-99959942023-03-10 Human CD8(+) T-Cell Populations That Express Natural Killer Receptors Koh, June-Young Kim, Dong-Uk Moon, Bae-Hyeon Shin, Eui-Cheol Immune Netw Review Article CD8(+) T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag recognition, CD8(+) T cells and NK cells play distinct roles as adaptive and innate immune cells, respectively. However, some human CD8(+) T cells have been found to express activating or inhibitory NK receptors. CD8(+) T-cell populations expressing NK receptors straddle the innate-adaptive boundary with their innate-like features. Recent breakthrough technical advances in multi-omics analysis have enabled elucidation of the unique immunologic characteristics of these populations. However, studies have not yet fully clarified the heterogeneity and immunological characteristics of each CD8(+) T-cell population expressing NK receptors. Here we aimed to review the current knowledge of various CD8(+) T-cell populations expressing NK receptors, and to pave the way for delineating the landscape and identifying the various roles of these T-cell populations. The Korean Association of Immunologists 2023-02-20 /pmc/articles/PMC9995994/ /pubmed/36911797 http://dx.doi.org/10.4110/in.2023.23.e8 Text en Copyright © 2023. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Koh, June-Young
Kim, Dong-Uk
Moon, Bae-Hyeon
Shin, Eui-Cheol
Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title_full Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title_fullStr Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title_full_unstemmed Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title_short Human CD8(+) T-Cell Populations That Express Natural Killer Receptors
title_sort human cd8(+) t-cell populations that express natural killer receptors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995994/
https://www.ncbi.nlm.nih.gov/pubmed/36911797
http://dx.doi.org/10.4110/in.2023.23.e8
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