Insights into bone morphogenetic proteins in cardiovascular diseases

Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progr...

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Autores principales: Ye, Di, Liu, Yinghui, Pan, Heng, Feng, Yongqi, Lu, Xiyi, Gan, Liren, Wan, Jun, Ye, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996008/
https://www.ncbi.nlm.nih.gov/pubmed/36909186
http://dx.doi.org/10.3389/fphar.2023.1125642
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author Ye, Di
Liu, Yinghui
Pan, Heng
Feng, Yongqi
Lu, Xiyi
Gan, Liren
Wan, Jun
Ye, Jing
author_facet Ye, Di
Liu, Yinghui
Pan, Heng
Feng, Yongqi
Lu, Xiyi
Gan, Liren
Wan, Jun
Ye, Jing
author_sort Ye, Di
collection PubMed
description Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
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spelling pubmed-99960082023-03-10 Insights into bone morphogenetic proteins in cardiovascular diseases Ye, Di Liu, Yinghui Pan, Heng Feng, Yongqi Lu, Xiyi Gan, Liren Wan, Jun Ye, Jing Front Pharmacol Pharmacology Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9996008/ /pubmed/36909186 http://dx.doi.org/10.3389/fphar.2023.1125642 Text en Copyright © 2023 Ye, Liu, Pan, Feng, Lu, Gan, Wan and Ye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ye, Di
Liu, Yinghui
Pan, Heng
Feng, Yongqi
Lu, Xiyi
Gan, Liren
Wan, Jun
Ye, Jing
Insights into bone morphogenetic proteins in cardiovascular diseases
title Insights into bone morphogenetic proteins in cardiovascular diseases
title_full Insights into bone morphogenetic proteins in cardiovascular diseases
title_fullStr Insights into bone morphogenetic proteins in cardiovascular diseases
title_full_unstemmed Insights into bone morphogenetic proteins in cardiovascular diseases
title_short Insights into bone morphogenetic proteins in cardiovascular diseases
title_sort insights into bone morphogenetic proteins in cardiovascular diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996008/
https://www.ncbi.nlm.nih.gov/pubmed/36909186
http://dx.doi.org/10.3389/fphar.2023.1125642
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