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Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software
BACKGROUND: Visuospatial dysfunction and cognitive impairment are common in Parkinson’s disease (PD), which draw increasing attention in the current literature. But clinicians still lack rapid, effective and unified cognitive battery for visuospatial assessment. OBJECTIVE: A new approach was studied...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996065/ https://www.ncbi.nlm.nih.gov/pubmed/36909949 http://dx.doi.org/10.3389/fnagi.2023.1108166 |
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author | Shao, Xu Wang, Kang Zhang, Yulian Zhen, Xueke Dong, Fen Tian, Hong Yu, Yanbing |
author_facet | Shao, Xu Wang, Kang Zhang, Yulian Zhen, Xueke Dong, Fen Tian, Hong Yu, Yanbing |
author_sort | Shao, Xu |
collection | PubMed |
description | BACKGROUND: Visuospatial dysfunction and cognitive impairment are common in Parkinson’s disease (PD), which draw increasing attention in the current literature. But clinicians still lack rapid, effective and unified cognitive battery for visuospatial assessment. OBJECTIVE: A new approach was studied to explore the feasibility of using mobile application software (APP) to evaluate visuospatial dysfunction in patients with PD and compared with traditional assessment tools. We aimed to verify the threshold score of the APP for early diagnosis. MATERIALS AND METHODS: A total of 41 patients with PD underwent assessments using several test modules including Digit Symbol Test (DST), Visual Organization Test (VOT), Facial Recognition Test (FRT), Vocabulary Memory Test (VMT) of this APP, as well as Clock Drawing Test (CDT), Cube Copying Test (CCT) and the Mini-Mental State Examination (MMSE) for comparison. Among the 41 PD patients, 30 individuals were found to have visuospatial dysfunction based on CDT score < 5 and CCT score of<18 while the remaining 11 patients served as control. RESULTS: There were statistically significant differences in DST, VOT, and FRT scores (all p ≤ 0.001 for group comparisons). DST, VOT, and FRT-1 were significantly correlated with MMSE, CDT and CCT and the correlations were moderate or fairly strong. For visuospatial dysfunction diagnosis, all the areas under curves (AUC) of DST, VOT, and FRT-1 were statistically significant (p < 0.0001, p = 0.0002, and p = 0.0002, respectively). The estimates and 95% confidence intervals of AUC were 0.8303 (0.6868, 0.9739), 0.8045 (0.6423, 0.9668), and 0.7833 (0.6344, 0.9322), respectively. Their cut-off points for visuospatial dysfunction were 26, 17, and 19, respectively. After dichotomization by the cut-off points, DST had high sensitivity of 96.67% while VOT and FRT-1 had high specificity of 81.82 and 90.91%. CONCLUSION: This study demonstrated that visuospatial disorders was highly prevalent in PD patients, and the APP used in study could be a practical clinical screening tool for visuospatial ability assessment with high sensitivity and specificity. |
format | Online Article Text |
id | pubmed-9996065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99960652023-03-10 Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software Shao, Xu Wang, Kang Zhang, Yulian Zhen, Xueke Dong, Fen Tian, Hong Yu, Yanbing Front Aging Neurosci Aging Neuroscience BACKGROUND: Visuospatial dysfunction and cognitive impairment are common in Parkinson’s disease (PD), which draw increasing attention in the current literature. But clinicians still lack rapid, effective and unified cognitive battery for visuospatial assessment. OBJECTIVE: A new approach was studied to explore the feasibility of using mobile application software (APP) to evaluate visuospatial dysfunction in patients with PD and compared with traditional assessment tools. We aimed to verify the threshold score of the APP for early diagnosis. MATERIALS AND METHODS: A total of 41 patients with PD underwent assessments using several test modules including Digit Symbol Test (DST), Visual Organization Test (VOT), Facial Recognition Test (FRT), Vocabulary Memory Test (VMT) of this APP, as well as Clock Drawing Test (CDT), Cube Copying Test (CCT) and the Mini-Mental State Examination (MMSE) for comparison. Among the 41 PD patients, 30 individuals were found to have visuospatial dysfunction based on CDT score < 5 and CCT score of<18 while the remaining 11 patients served as control. RESULTS: There were statistically significant differences in DST, VOT, and FRT scores (all p ≤ 0.001 for group comparisons). DST, VOT, and FRT-1 were significantly correlated with MMSE, CDT and CCT and the correlations were moderate or fairly strong. For visuospatial dysfunction diagnosis, all the areas under curves (AUC) of DST, VOT, and FRT-1 were statistically significant (p < 0.0001, p = 0.0002, and p = 0.0002, respectively). The estimates and 95% confidence intervals of AUC were 0.8303 (0.6868, 0.9739), 0.8045 (0.6423, 0.9668), and 0.7833 (0.6344, 0.9322), respectively. Their cut-off points for visuospatial dysfunction were 26, 17, and 19, respectively. After dichotomization by the cut-off points, DST had high sensitivity of 96.67% while VOT and FRT-1 had high specificity of 81.82 and 90.91%. CONCLUSION: This study demonstrated that visuospatial disorders was highly prevalent in PD patients, and the APP used in study could be a practical clinical screening tool for visuospatial ability assessment with high sensitivity and specificity. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9996065/ /pubmed/36909949 http://dx.doi.org/10.3389/fnagi.2023.1108166 Text en Copyright © 2023 Shao, Wang, Zhang, Zhen, Dong, Tian and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Shao, Xu Wang, Kang Zhang, Yulian Zhen, Xueke Dong, Fen Tian, Hong Yu, Yanbing Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title | Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title_full | Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title_fullStr | Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title_full_unstemmed | Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title_short | Outcome of visuospatial dysfunction assessment in patients with Parkinson’s disease using mobile application software |
title_sort | outcome of visuospatial dysfunction assessment in patients with parkinson’s disease using mobile application software |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996065/ https://www.ncbi.nlm.nih.gov/pubmed/36909949 http://dx.doi.org/10.3389/fnagi.2023.1108166 |
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