A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites

BACKGROUND: Macrophages at infection sites are considered as the promising therapeutic targets to prevent sepsis development. The Nrf2/Keap1 system acts as a critical modulator of the antibacterial activity of macrophages. Recently, Keap1–Nrf2 protein–protein interaction (PPI) inhibitors have emerge...

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Detalles Bibliográficos
Autores principales: Wang, Yawei, Tang, Binlin, Li, Huijuan, Zheng, Jiancheng, Zhang, Can, Yang, Zeyu, Tan, Xu, Luo, Peng, Ma, Le, Wang, Yang, Long, Lei, Chen, Zelin, Xiao, Zhenliang, Ma, Lijie, Zhou, Jing, Wang, Yu, Shi, Chunmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996215/
https://www.ncbi.nlm.nih.gov/pubmed/36863256
http://dx.doi.org/10.1016/j.ebiom.2023.104480

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