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A novel current steering method for targeted spinal cord stimulation

Spinal Cord Stimulation (SCS) with leads embedded in the epidural space has become a recognized and effective clinical therapy for chronic pain relief. Leads with multiple electrodes placed close to the spinal cord allow targeted stimulation. This paper presents a novel current steering method to ac...

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Autores principales: Mishra, Lakshmi Narayan, Kulkarni, Gaurav, Gadgil, Mandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996238/
https://www.ncbi.nlm.nih.gov/pubmed/36910254
http://dx.doi.org/10.3389/fpain.2023.1028368
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author Mishra, Lakshmi Narayan
Kulkarni, Gaurav
Gadgil, Mandar
author_facet Mishra, Lakshmi Narayan
Kulkarni, Gaurav
Gadgil, Mandar
author_sort Mishra, Lakshmi Narayan
collection PubMed
description Spinal Cord Stimulation (SCS) with leads embedded in the epidural space has become a recognized and effective clinical therapy for chronic pain relief. Leads with multiple electrodes placed close to the spinal cord allow targeted stimulation. This paper presents a novel current steering method to achieve targeted spinal cord stimulation by determining the optimal current sourced through a set of electrodes to maximize current density in a specified region of the spinal cord. The method provides a flexibility for personalized pain relief therapy, while minimizing stimulation in unwanted regions. The paper proposes a new optimization problem to achieve current steering. The optimization problem uses a solution of the Poisson equation evaluated using Finite Element Analysis (FEA) over a geometric model of the spinal cord and the embedded leads. The solution to the optimization problem determines the optimal current sourced through a set of electrodes to achieve a targeted stimulation.
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spelling pubmed-99962382023-03-10 A novel current steering method for targeted spinal cord stimulation Mishra, Lakshmi Narayan Kulkarni, Gaurav Gadgil, Mandar Front Pain Res (Lausanne) Pain Research Spinal Cord Stimulation (SCS) with leads embedded in the epidural space has become a recognized and effective clinical therapy for chronic pain relief. Leads with multiple electrodes placed close to the spinal cord allow targeted stimulation. This paper presents a novel current steering method to achieve targeted spinal cord stimulation by determining the optimal current sourced through a set of electrodes to maximize current density in a specified region of the spinal cord. The method provides a flexibility for personalized pain relief therapy, while minimizing stimulation in unwanted regions. The paper proposes a new optimization problem to achieve current steering. The optimization problem uses a solution of the Poisson equation evaluated using Finite Element Analysis (FEA) over a geometric model of the spinal cord and the embedded leads. The solution to the optimization problem determines the optimal current sourced through a set of electrodes to achieve a targeted stimulation. Frontiers Media S.A. 2023-02-23 /pmc/articles/PMC9996238/ /pubmed/36910254 http://dx.doi.org/10.3389/fpain.2023.1028368 Text en © 2023 Mishra, Kulkarni and Gadgil. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Mishra, Lakshmi Narayan
Kulkarni, Gaurav
Gadgil, Mandar
A novel current steering method for targeted spinal cord stimulation
title A novel current steering method for targeted spinal cord stimulation
title_full A novel current steering method for targeted spinal cord stimulation
title_fullStr A novel current steering method for targeted spinal cord stimulation
title_full_unstemmed A novel current steering method for targeted spinal cord stimulation
title_short A novel current steering method for targeted spinal cord stimulation
title_sort novel current steering method for targeted spinal cord stimulation
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996238/
https://www.ncbi.nlm.nih.gov/pubmed/36910254
http://dx.doi.org/10.3389/fpain.2023.1028368
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