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Chemically modified aptamers for improving binding affinity to the target proteins via enhanced non-covalent bonding

Nucleic acid aptamers are ssDNA or ssRNA fragments that specifically recognize targets. However, the pharmacodynamic properties of natural aptamers consisting of 4 naturally occurring nucleosides (A, G, C, T/U) are generally restricted for inferior binding affinity than the cognate antibodies. The d...

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Detalles Bibliográficos
Autores principales:	Chen, Zefeng, Luo, Hang, Gubu, Amu, Yu, Sifan, Zhang, Huarui, Dai, Hong, Zhang, Yihao, Zhang, Baoting, Ma, Yuan, Lu, Aiping, Zhang, Ge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996316/ https://www.ncbi.nlm.nih.gov/pubmed/36910146 http://dx.doi.org/10.3389/fcell.2023.1091809

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