Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells

BACKGROUND & AIMS: Patterns of liver HBV antigen expression have been described but not quantified at single-cell resolution. We applied quantitative techniques to liver biopsies from individuals with chronic hepatitis B and evaluated sampling heterogeneity, effects of disease stage, and nucleos...

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Detalles Bibliográficos
Autores principales: Aggarwal, Abhishek, Odorizzi, Pamela M., Brodbeck, Jens, van Buuren, Nicholas, Moon, Christina, Chang, Silvia, Adona, MaryVic, Suthram, Silpa, Suri, Vithika, Trowe, Torsten, Turner, Scott, Marcellin, Patrick, Buti, Maria, Gaggar, Anuj, Fletcher, Simon P., Diehl, Lauri, Feierbach, Becket, Balsitis, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996321/
https://www.ncbi.nlm.nih.gov/pubmed/36908748
http://dx.doi.org/10.1016/j.jhepr.2022.100664

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