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Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR

Inorganic arsenic (iAs) is an environmental toxicant that can lead to severe health consequences, which can be exacerbated if exposure occurs early in development. Here, we evaluated the impact of oral iAs treatment on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and bilirubin metabolism in h...

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Detalles Bibliográficos
Autores principales:	Yang, Xiaojing, Weber, André A., Mennillo, Elvira, Paszek, Miles, Wong, Samantha, Le, Sabrina, Teo, Jia Ying Ashley, Chang, Max, Benner, Christopher W., Tukey, Robert H., Chen, Shujuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996368/ https://www.ncbi.nlm.nih.gov/pubmed/36720308 http://dx.doi.org/10.1016/j.jbc.2023.102955

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