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The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease

Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...

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Detalles Bibliográficos
Autores principales:	Baek, Judy, Sas, Kelli, He, Chenchen, Nair, Viji, Giblin, William, Inoki, Ayaka, Zhang, Hongyu, Yingbao, Yang, Hodgin, Jeffrey, Nelson, Robert G., Brosius, Frank C., Kretzler, Matthias, Stemmer, Paul M., Lombard, David B., Pennathur, Subramaniam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996370/ https://www.ncbi.nlm.nih.gov/pubmed/36736426 http://dx.doi.org/10.1016/j.jbc.2023.102960

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