TCR sequencing: applications in immuno-oncology research

• T-cell receptor (TCR) interaction with major histocompatibility complex–antigen complexes leads to antitumour responses. • TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens. • T-cell clonal revival and clonal replacement potentially underpin immunotherapy...

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Detalles Bibliográficos
Autores principales: Sanromán, Á.F., Joshi, K., Au, L., Chain, B., Turajlic, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996383/
https://www.ncbi.nlm.nih.gov/pubmed/36908996
http://dx.doi.org/10.1016/j.iotech.2023.100373
Descripción
Sumario:• T-cell receptor (TCR) interaction with major histocompatibility complex–antigen complexes leads to antitumour responses. • TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens. • T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses.

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