TCR sequencing: applications in immuno-oncology research

• T-cell receptor (TCR) interaction with major histocompatibility complex–antigen complexes leads to antitumour responses. • TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens. • T-cell clonal revival and clonal replacement potentially underpin immunotherapy...

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Detalles Bibliográficos
Autores principales: Sanromán, Á.F., Joshi, K., Au, L., Chain, B., Turajlic, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996383/
https://www.ncbi.nlm.nih.gov/pubmed/36908996
http://dx.doi.org/10.1016/j.iotech.2023.100373
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author Sanromán, Á.F.
Joshi, K.
Au, L.
Chain, B.
Turajlic, S.
author_facet Sanromán, Á.F.
Joshi, K.
Au, L.
Chain, B.
Turajlic, S.
author_sort Sanromán, Á.F.
collection PubMed
description • T-cell receptor (TCR) interaction with major histocompatibility complex–antigen complexes leads to antitumour responses. • TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens. • T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses.
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spelling pubmed-99963832023-03-10 TCR sequencing: applications in immuno-oncology research Sanromán, Á.F. Joshi, K. Au, L. Chain, B. Turajlic, S. Immunooncol Technol Review • T-cell receptor (TCR) interaction with major histocompatibility complex–antigen complexes leads to antitumour responses. • TCR sequencing analysis allows characterisation of T cells that recognise tumour neoantigens. • T-cell clonal revival and clonal replacement potentially underpin immunotherapy responses. Elsevier 2023-02-04 /pmc/articles/PMC9996383/ /pubmed/36908996 http://dx.doi.org/10.1016/j.iotech.2023.100373 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sanromán, Á.F.
Joshi, K.
Au, L.
Chain, B.
Turajlic, S.
TCR sequencing: applications in immuno-oncology research
title TCR sequencing: applications in immuno-oncology research
title_full TCR sequencing: applications in immuno-oncology research
title_fullStr TCR sequencing: applications in immuno-oncology research
title_full_unstemmed TCR sequencing: applications in immuno-oncology research
title_short TCR sequencing: applications in immuno-oncology research
title_sort tcr sequencing: applications in immuno-oncology research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996383/
https://www.ncbi.nlm.nih.gov/pubmed/36908996
http://dx.doi.org/10.1016/j.iotech.2023.100373
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