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Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure

AIM: Immune checkpoint inhibitor (ICI) efficacy is undefined for melanoma brain metastases (MBM) with concurrent corticosteroid exposure. MATERIALS & METHODS: We retrospectively evaluated patients with untreated MBM who received corticosteroids (≥1.5 mg dexamethasone equivalent) within 30 days o...

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Autores principales: Tringale, Kathryn R, Reiner, Anne S, Sehgal, Ryka R, Panageas, Katherine, Betof Warner, Allison S, Postow, Michael A, Moss, Nelson S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996406/
https://www.ncbi.nlm.nih.gov/pubmed/36802833
http://dx.doi.org/10.2217/cns-2022-0014
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author Tringale, Kathryn R
Reiner, Anne S
Sehgal, Ryka R
Panageas, Katherine
Betof Warner, Allison S
Postow, Michael A
Moss, Nelson S
author_facet Tringale, Kathryn R
Reiner, Anne S
Sehgal, Ryka R
Panageas, Katherine
Betof Warner, Allison S
Postow, Michael A
Moss, Nelson S
author_sort Tringale, Kathryn R
collection PubMed
description AIM: Immune checkpoint inhibitor (ICI) efficacy is undefined for melanoma brain metastases (MBM) with concurrent corticosteroid exposure. MATERIALS & METHODS: We retrospectively evaluated patients with untreated MBM who received corticosteroids (≥1.5 mg dexamethasone equivalent) within 30 days of ICI. mRECIST criteria and Kaplan–Meier methods defined intracranial progression-free survival (iPFS). The lesion size-response association was evaluated with repeated measures modeling. RESULTS: A total of 109 MBM were evaluated. The patient level intracranial response rate was 41%. Median iPFS was 2.3 months and overall survival was 13.4 months. Larger lesions were more likely to progress, with diameter >2.05 cm most predictive of progression (OR: 18.9; 95% CI: 2.6–139.5; p = 0.004). There was no difference in iPFS with steroid exposure pre- versus post-ICI initiation. CONCLUSION: In the largest reported ICI+corticosteroid cohort, we identify size dependent MBM response.
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spelling pubmed-99964062023-03-10 Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure Tringale, Kathryn R Reiner, Anne S Sehgal, Ryka R Panageas, Katherine Betof Warner, Allison S Postow, Michael A Moss, Nelson S CNS Oncol Research Article AIM: Immune checkpoint inhibitor (ICI) efficacy is undefined for melanoma brain metastases (MBM) with concurrent corticosteroid exposure. MATERIALS & METHODS: We retrospectively evaluated patients with untreated MBM who received corticosteroids (≥1.5 mg dexamethasone equivalent) within 30 days of ICI. mRECIST criteria and Kaplan–Meier methods defined intracranial progression-free survival (iPFS). The lesion size-response association was evaluated with repeated measures modeling. RESULTS: A total of 109 MBM were evaluated. The patient level intracranial response rate was 41%. Median iPFS was 2.3 months and overall survival was 13.4 months. Larger lesions were more likely to progress, with diameter >2.05 cm most predictive of progression (OR: 18.9; 95% CI: 2.6–139.5; p = 0.004). There was no difference in iPFS with steroid exposure pre- versus post-ICI initiation. CONCLUSION: In the largest reported ICI+corticosteroid cohort, we identify size dependent MBM response. Future Medicine Ltd 2023-02-20 /pmc/articles/PMC9996406/ /pubmed/36802833 http://dx.doi.org/10.2217/cns-2022-0014 Text en © 2023 Memorial Sloan Kettering Cancer Center https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Tringale, Kathryn R
Reiner, Anne S
Sehgal, Ryka R
Panageas, Katherine
Betof Warner, Allison S
Postow, Michael A
Moss, Nelson S
Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title_full Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title_fullStr Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title_full_unstemmed Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title_short Efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
title_sort efficacy of immunotherapy for melanoma brain metastases in patients with concurrent corticosteroid exposure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996406/
https://www.ncbi.nlm.nih.gov/pubmed/36802833
http://dx.doi.org/10.2217/cns-2022-0014
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