IP(3)Rs puff along: A SNAPpy dance with IP(3) and Ca(2+)

Concerted openings of clustered inositol 1,4,5-trisphosphate receptors (IP(3)Rs) result in short, localized Ca(2+) bursts, also called puffs, which are crucial regulators of Ca(2+)-dependent signaling processes. However, the processes regulating Ca(2+) puff amplitude (average ∼0.5 ΔF/F(0)) and durat...

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Detalles Bibliográficos
Autores principales: Nakhe, Arya Y., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996433/
https://www.ncbi.nlm.nih.gov/pubmed/36773801
http://dx.doi.org/10.1016/j.jbc.2023.103010
Descripción
Sumario:Concerted openings of clustered inositol 1,4,5-trisphosphate receptors (IP(3)Rs) result in short, localized Ca(2+) bursts, also called puffs, which are crucial regulators of Ca(2+)-dependent signaling processes. However, the processes regulating Ca(2+) puff amplitude (average ∼0.5 ΔF/F(0)) and duration (at half-maximal; average ∼25-30 ms) have yet to be elucidated. A recent study in JBC by Smith and Taylor determined that Ca(2+) puff amplitude is independent of IP(3)R cluster density and that the termination of IP(3)R Ca(2+) puff is regulated by IP(3) dissociation, illuminating the steps of this regulatory dance.

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