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Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

Genotoxicity and mutagenicity of monoterpene carvone along with the related monoterpene alcohols – carvacrol and thymol have been studied using Drosophila melanogaster as model system. The viability, pre-imaginal stage duration, level of dominant lethal mutations, unequal crossover in the Bar mutant...

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Autores principales: Nesterkina, Mariia, Bilokon, Svitlana, Alieksieieva, Tetiana, Kravchenko, Iryna, Hirsch, Anna K.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996437/
https://www.ncbi.nlm.nih.gov/pubmed/36911165
http://dx.doi.org/10.1016/j.toxrep.2023.02.009
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author Nesterkina, Mariia
Bilokon, Svitlana
Alieksieieva, Tetiana
Kravchenko, Iryna
Hirsch, Anna K.H.
author_facet Nesterkina, Mariia
Bilokon, Svitlana
Alieksieieva, Tetiana
Kravchenko, Iryna
Hirsch, Anna K.H.
author_sort Nesterkina, Mariia
collection PubMed
description Genotoxicity and mutagenicity of monoterpene carvone along with the related monoterpene alcohols – carvacrol and thymol have been studied using Drosophila melanogaster as model system. The viability, pre-imaginal stage duration, level of dominant lethal mutations, unequal crossover in the Bar mutant of D. melanogaster and the influence of monocyclic terpenoids on the multiplication of the nuclear genome in salivary gland cells were investigated. The compounds tested after oral administration (0.02% in 1,2-propylene glycol) influence the degree of chromosome polyteny in salivary gland cells of D. melanogaster larvae. Among the terpenoids examined, carvacrol exhibited the most significant impact on imago lifespan, frequency of dominant lethal mutations, unequal crossover in the Bar mutant when added to the culture medium. Oral administration of terpenoids increases the average level of chromosome polyteny with the highest value for carvacrol – 1178 C compared to control (776 C). The conceivable mechanism of action for monocyclic terpenoids associated with the impact on juvenile hormone activity is debated.
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spelling pubmed-99964372023-03-10 Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster Nesterkina, Mariia Bilokon, Svitlana Alieksieieva, Tetiana Kravchenko, Iryna Hirsch, Anna K.H. Toxicol Rep Article Genotoxicity and mutagenicity of monoterpene carvone along with the related monoterpene alcohols – carvacrol and thymol have been studied using Drosophila melanogaster as model system. The viability, pre-imaginal stage duration, level of dominant lethal mutations, unequal crossover in the Bar mutant of D. melanogaster and the influence of monocyclic terpenoids on the multiplication of the nuclear genome in salivary gland cells were investigated. The compounds tested after oral administration (0.02% in 1,2-propylene glycol) influence the degree of chromosome polyteny in salivary gland cells of D. melanogaster larvae. Among the terpenoids examined, carvacrol exhibited the most significant impact on imago lifespan, frequency of dominant lethal mutations, unequal crossover in the Bar mutant when added to the culture medium. Oral administration of terpenoids increases the average level of chromosome polyteny with the highest value for carvacrol – 1178 C compared to control (776 C). The conceivable mechanism of action for monocyclic terpenoids associated with the impact on juvenile hormone activity is debated. Elsevier 2023-02-23 /pmc/articles/PMC9996437/ /pubmed/36911165 http://dx.doi.org/10.1016/j.toxrep.2023.02.009 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Nesterkina, Mariia
Bilokon, Svitlana
Alieksieieva, Tetiana
Kravchenko, Iryna
Hirsch, Anna K.H.
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title_full Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title_fullStr Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title_full_unstemmed Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title_short Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
title_sort genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in drosophila melanogaster
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996437/
https://www.ncbi.nlm.nih.gov/pubmed/36911165
http://dx.doi.org/10.1016/j.toxrep.2023.02.009
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