Cargando…

Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers

PURPOSE OF REVIEW: The purpose of this paper is to provide a focused update on recent advances in non-18F-FDG radiotracers for myocardial inflammatory diseases, with a focus on cardiac sarcoidosis and myocarditis. RECENT FINDINGS: Novel radiotracers targeting molecular features of inflammation have...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Tiantian, Miller, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996562/
https://www.ncbi.nlm.nih.gov/pubmed/36926261
http://dx.doi.org/10.1007/s12410-023-09574-4
_version_ 1784903071125471232
author Shi, Tiantian
Miller, Edward J.
author_facet Shi, Tiantian
Miller, Edward J.
author_sort Shi, Tiantian
collection PubMed
description PURPOSE OF REVIEW: The purpose of this paper is to provide a focused update on recent advances in non-18F-FDG radiotracers for myocardial inflammatory diseases, with a focus on cardiac sarcoidosis and myocarditis. RECENT FINDINGS: Novel radiotracers targeting molecular features of inflammation have the potential to visualize underlying molecular mechanisms key to the pathogenesis of inflammatory cardiomyopathies such as sarcoidosis and myocarditis. These radiotracers may provide unique opportunities for improved mechanistic insight, higher specificity, and better quantification of disease activity, as well as potential for guidance and monitoring of immunomodulatory therapies. SUMMARY: Novel radiotracers provide unique possibilities in diagnosis, prognostic performance, and therapy guidance for cardiac sarcoidosis and myocarditis.
format Online
Article
Text
id pubmed-9996562
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-99965622023-03-09 Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers Shi, Tiantian Miller, Edward J. Curr Cardiovasc Imaging Rep Article PURPOSE OF REVIEW: The purpose of this paper is to provide a focused update on recent advances in non-18F-FDG radiotracers for myocardial inflammatory diseases, with a focus on cardiac sarcoidosis and myocarditis. RECENT FINDINGS: Novel radiotracers targeting molecular features of inflammation have the potential to visualize underlying molecular mechanisms key to the pathogenesis of inflammatory cardiomyopathies such as sarcoidosis and myocarditis. These radiotracers may provide unique opportunities for improved mechanistic insight, higher specificity, and better quantification of disease activity, as well as potential for guidance and monitoring of immunomodulatory therapies. SUMMARY: Novel radiotracers provide unique possibilities in diagnosis, prognostic performance, and therapy guidance for cardiac sarcoidosis and myocarditis. Springer US 2023-03-09 2023 /pmc/articles/PMC9996562/ /pubmed/36926261 http://dx.doi.org/10.1007/s12410-023-09574-4 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Shi, Tiantian
Miller, Edward J.
Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title_full Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title_fullStr Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title_full_unstemmed Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title_short Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
title_sort novel radiotracers for molecular imaging of myocardial inflammation: an update focused on clinical translation of non-18f-fdg radiotracers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996562/
https://www.ncbi.nlm.nih.gov/pubmed/36926261
http://dx.doi.org/10.1007/s12410-023-09574-4
work_keys_str_mv AT shitiantian novelradiotracersformolecularimagingofmyocardialinflammationanupdatefocusedonclinicaltranslationofnon18ffdgradiotracers
AT milleredwardj novelradiotracersformolecularimagingofmyocardialinflammationanupdatefocusedonclinicaltranslationofnon18ffdgradiotracers