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Integrated Glass Microfluidics with Electrochemical Nanogap Electrodes

[Image: see text] We present a framework for the fabrication of chip-based electrochemical nanogap sensors integrated with microfluidics. Instead of polydimethylsiloxane (PDMS), SU-8 aided adhesive bonding of silicon and glass wafers is used to implement parallel flow control. The fabrication proces...

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Detalles Bibliográficos
Autores principales: Sarkar, Sahana, Nieuwenhuis, Ab F., Lemay, Serge G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996602/
https://www.ncbi.nlm.nih.gov/pubmed/36812004
http://dx.doi.org/10.1021/acs.analchem.2c04257
Descripción
Sumario:[Image: see text] We present a framework for the fabrication of chip-based electrochemical nanogap sensors integrated with microfluidics. Instead of polydimethylsiloxane (PDMS), SU-8 aided adhesive bonding of silicon and glass wafers is used to implement parallel flow control. The fabrication process permits wafer-scale production with high throughput and reproducibility. Additionally, the monolithic structures allow simple electrical and fluidic connections, alleviating the need for specialized equipment. We demonstrate the utility of these flow-incorporated nanogap sensors by performing redox cycling measurements under laminar flow conditions.