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Human Glucosylceramide Synthase at Work as Provided by “In Silico” Molecular Docking, Molecular Dynamics, and Metadynamics

[Image: see text] Glucosylceramide synthase (GCS) is an enzyme that catalyzes the first reaction of ceramide glycosylation in sphingolipid metabolism. It represents a primary target in the pharmacological treatment of some lysosomal storage diseases (LSDs), such as Gaucher and Niemann-Pick syndromes...

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Detalles Bibliográficos
Autores principales:	Canini, Giorgia, Lo Cascio, Ettore, Della Longa, Stefano, Cecconi, Francesco, Arcovito, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996764/ https://www.ncbi.nlm.nih.gov/pubmed/36910965 http://dx.doi.org/10.1021/acsomega.2c08219

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