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Non-active Site Residue in Loop L4 Alters Substrate Capture and Product Release in d-Arginine Dehydrogenase

[Image: see text] Numerous studies demonstrate that enzymes undergo multiple conformational changes during catalysis. The malleability of enzymes forms the basis for allosteric regulation: residues located far from the active site can exert long-range dynamical effects on the active site residues to...

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Detalles Bibliográficos
Autores principales: Ouedraogo, Daniel, Souffrant, Michael, Yao, Xin-Qiu, Hamelberg, Donald, Gadda, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996824/
https://www.ncbi.nlm.nih.gov/pubmed/36795942
http://dx.doi.org/10.1021/acs.biochem.2c00697

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