Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv background have a slow and fast disease progression rate, mimicking the variability obs...

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Detalles Bibliográficos
Autores principales: Margotta, Cassandra, Fabbrizio, Paola, Ceccanti, Marco, Cambieri, Chiara, Ruffolo, Gabriele, D’Agostino, Jessica, Trolese, Maria Chiara, Cifelli, Pierangelo, Alfano, Veronica, Laurini, Christian, Scaricamazza, Silvia, Ferri, Alberto, Sorarù, Gianni, Palma, Eleonora, Inghilleri, Maurizio, Bendotti, Caterina, Nardo, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996869/
https://www.ncbi.nlm.nih.gov/pubmed/36895050
http://dx.doi.org/10.1186/s41232-023-00270-w

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