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Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients

BACKGROUND: Left ventricular hypertrophy (LVH) and carotid atherosclerosis (CAS) have been identified as factors associated with cognitive impairment (CI) but have not been studied in patients undergoing peritoneal dialysis (PD). This study investigated the relationship between LVH and CAS and cogni...

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Autores principales: Zhu, Xuejing, Jing, Ran, Li, XiaoPing, Zhang, Wanfen, Tang, Yushang, Liu, Tongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996916/
https://www.ncbi.nlm.nih.gov/pubmed/36890445
http://dx.doi.org/10.1186/s12872-023-03130-0
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author Zhu, Xuejing
Jing, Ran
Li, XiaoPing
Zhang, Wanfen
Tang, Yushang
Liu, Tongqiang
author_facet Zhu, Xuejing
Jing, Ran
Li, XiaoPing
Zhang, Wanfen
Tang, Yushang
Liu, Tongqiang
author_sort Zhu, Xuejing
collection PubMed
description BACKGROUND: Left ventricular hypertrophy (LVH) and carotid atherosclerosis (CAS) have been identified as factors associated with cognitive impairment (CI) but have not been studied in patients undergoing peritoneal dialysis (PD). This study investigated the relationship between LVH and CAS and cognitive function in patients undergoing PD. METHODS: In this single-center cross-sectional study, the clinically stable patients who were over 18 years of age and had undergone PD for at least 3 months were enrolled. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), which included seven areas: visuospatial/executive function, naming, attention, language, abstraction, delayed recall, and orientation. LVH was defined as LVMI > 46.7 g/m(2.7) in women and LVMI > 49.2 g/m(2.7) in men. CAS was defined as carotid intima-media thickness ≥ 1.0 mm and/or the presence of plaque. RESULTS: A total of 207 patients undergoing PD were recruited, with an average age of 52.14 ± 14.93 years and a median PD duration of 8 months (5–19 months). The CI rate was 56%, and the prevalence of CAS was 53.6%. LVH occurred in 110 patients (53.1%). Patients in the LVH group tended to be older, and had a higher body mass index, a higher pulse pressure, a higher male proportion, a lower ejection fraction, a higher prevalence of cardiovascular disease and CI, and a lower MoCA scores.Multivariate logistic regression analysis was conducted to analyze the association between LVH and CI (OR, 10.087; 95% confidence interval, 2.966–34.307). And the association between LVH and CI was still supported after propensity matching scores. CAS was not significantly associated with CI. CONCLUSION: LVH is independently associated with CI in patients undergoing PD, while CAS is not significantly associated with CI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03130-0.
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spelling pubmed-99969162023-03-10 Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients Zhu, Xuejing Jing, Ran Li, XiaoPing Zhang, Wanfen Tang, Yushang Liu, Tongqiang BMC Cardiovasc Disord Research BACKGROUND: Left ventricular hypertrophy (LVH) and carotid atherosclerosis (CAS) have been identified as factors associated with cognitive impairment (CI) but have not been studied in patients undergoing peritoneal dialysis (PD). This study investigated the relationship between LVH and CAS and cognitive function in patients undergoing PD. METHODS: In this single-center cross-sectional study, the clinically stable patients who were over 18 years of age and had undergone PD for at least 3 months were enrolled. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), which included seven areas: visuospatial/executive function, naming, attention, language, abstraction, delayed recall, and orientation. LVH was defined as LVMI > 46.7 g/m(2.7) in women and LVMI > 49.2 g/m(2.7) in men. CAS was defined as carotid intima-media thickness ≥ 1.0 mm and/or the presence of plaque. RESULTS: A total of 207 patients undergoing PD were recruited, with an average age of 52.14 ± 14.93 years and a median PD duration of 8 months (5–19 months). The CI rate was 56%, and the prevalence of CAS was 53.6%. LVH occurred in 110 patients (53.1%). Patients in the LVH group tended to be older, and had a higher body mass index, a higher pulse pressure, a higher male proportion, a lower ejection fraction, a higher prevalence of cardiovascular disease and CI, and a lower MoCA scores.Multivariate logistic regression analysis was conducted to analyze the association between LVH and CI (OR, 10.087; 95% confidence interval, 2.966–34.307). And the association between LVH and CI was still supported after propensity matching scores. CAS was not significantly associated with CI. CONCLUSION: LVH is independently associated with CI in patients undergoing PD, while CAS is not significantly associated with CI. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03130-0. BioMed Central 2023-03-09 /pmc/articles/PMC9996916/ /pubmed/36890445 http://dx.doi.org/10.1186/s12872-023-03130-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhu, Xuejing
Jing, Ran
Li, XiaoPing
Zhang, Wanfen
Tang, Yushang
Liu, Tongqiang
Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title_full Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title_fullStr Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title_full_unstemmed Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title_short Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
title_sort left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996916/
https://www.ncbi.nlm.nih.gov/pubmed/36890445
http://dx.doi.org/10.1186/s12872-023-03130-0
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