Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

BACKGROUND: Persistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of inflammasomes, molecular platforms that drive inflammation through caspase-1-mediated proteolytic cleavage of proinflammator...

Descripción completa

Detalles Bibliográficos
Autores principales: de Dios, Cristina, Abadin, Xenia, Roca-Agujetas, Vicente, Jimenez-Martinez, Marina, Morales, Albert, Trullas, Ramon, Mari, Montserrat, Colell, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996936/
https://www.ncbi.nlm.nih.gov/pubmed/36895045
http://dx.doi.org/10.1186/s40035-023-00343-3

Ejemplares similares

Ejemplares similares