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Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up
Background: Since the early 1980s, human immunodeficiency virus (HIV) and its accompanying acquired immunodeficiency syndrome (AIDS) have spread worldwide, becoming one of the world's major global health issues. From the beginning of the epidemic until 2020, about 79.3 million people became inf...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997043/ https://www.ncbi.nlm.nih.gov/pubmed/36910027 http://dx.doi.org/10.12688/f1000research.123693.2 |
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author | Abiodun, Oluwakemi E. Adebimpe, Olukayode Ndako, James Oludoun, Olajumoke Aladeitan, Benedicta Adeniyi, Michael |
author_facet | Abiodun, Oluwakemi E. Adebimpe, Olukayode Ndako, James Oludoun, Olajumoke Aladeitan, Benedicta Adeniyi, Michael |
author_sort | Abiodun, Oluwakemi E. |
collection | PubMed |
description | Background: Since the early 1980s, human immunodeficiency virus (HIV) and its accompanying acquired immunodeficiency syndrome (AIDS) have spread worldwide, becoming one of the world's major global health issues. From the beginning of the epidemic until 2020, about 79.3 million people became infected, with 36.3 million deaths due to AIDS illnesses. This huge figure is a result of those unaware of their status due to stigmatization and invariably spreading the virus unknowingly. Methods: Qualitative analysis through a mathematical model that will address HIV unaware individuals and the effect of an increasing defaulter on the dynamics of HIV/AIDS was investigated. The impact of treatment and the effect of inefficient follow-up on the transmission of HIV/AIDS were examined. The threshold for the effective reduction of the unaware status of HIV through testing, in response to awareness, and the significance of effective non-defaulting in treatment commonly called defaulters loss to follow-up as these individuals contribute immensely to the spread of the virus due to their increase in CD4+ count was determined in this study. Stability analysis of equilibrium points is performed using the basic reproduction number $R_0$, an epidemiological threshold that determines disease eradication or persistence in viral populations. We tested the most sensitive parameters in the basic reproduction numbers. Results: The results portray that early identification and treatment only are inadequate for the illness to be eradicated, but effectively used of condom, strict adherence to treatment and counseling of and testing of pregnant women contribute to a decrease in infected HIV individuals. Conclusions: Other control techniques, such as treatment adherence and effective condom usage, and reduction in vertical transmission cannot be over-emphasis to lessen the disease's burden. Policymakers must address these strategies through a series of public awareness campaigns about the dangers of not adhering to treatment procedures and patterns. |
format | Online Article Text |
id | pubmed-9997043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-99970432023-03-10 Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up Abiodun, Oluwakemi E. Adebimpe, Olukayode Ndako, James Oludoun, Olajumoke Aladeitan, Benedicta Adeniyi, Michael F1000Res Research Article Background: Since the early 1980s, human immunodeficiency virus (HIV) and its accompanying acquired immunodeficiency syndrome (AIDS) have spread worldwide, becoming one of the world's major global health issues. From the beginning of the epidemic until 2020, about 79.3 million people became infected, with 36.3 million deaths due to AIDS illnesses. This huge figure is a result of those unaware of their status due to stigmatization and invariably spreading the virus unknowingly. Methods: Qualitative analysis through a mathematical model that will address HIV unaware individuals and the effect of an increasing defaulter on the dynamics of HIV/AIDS was investigated. The impact of treatment and the effect of inefficient follow-up on the transmission of HIV/AIDS were examined. The threshold for the effective reduction of the unaware status of HIV through testing, in response to awareness, and the significance of effective non-defaulting in treatment commonly called defaulters loss to follow-up as these individuals contribute immensely to the spread of the virus due to their increase in CD4+ count was determined in this study. Stability analysis of equilibrium points is performed using the basic reproduction number $R_0$, an epidemiological threshold that determines disease eradication or persistence in viral populations. We tested the most sensitive parameters in the basic reproduction numbers. Results: The results portray that early identification and treatment only are inadequate for the illness to be eradicated, but effectively used of condom, strict adherence to treatment and counseling of and testing of pregnant women contribute to a decrease in infected HIV individuals. Conclusions: Other control techniques, such as treatment adherence and effective condom usage, and reduction in vertical transmission cannot be over-emphasis to lessen the disease's burden. Policymakers must address these strategies through a series of public awareness campaigns about the dangers of not adhering to treatment procedures and patterns. F1000 Research Limited 2023-02-28 /pmc/articles/PMC9997043/ /pubmed/36910027 http://dx.doi.org/10.12688/f1000research.123693.2 Text en Copyright: © 2023 Abiodun OE et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Abiodun, Oluwakemi E. Adebimpe, Olukayode Ndako, James Oludoun, Olajumoke Aladeitan, Benedicta Adeniyi, Michael Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title | Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title_full | Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title_fullStr | Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title_full_unstemmed | Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title_short | Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up |
title_sort | qualitative analysis of hiv and aids disease transmission: impact of awareness, testing and effective follow up |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997043/ https://www.ncbi.nlm.nih.gov/pubmed/36910027 http://dx.doi.org/10.12688/f1000research.123693.2 |
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