Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications

[Image: see text] The binding processes of two Polo-like kinase inhibitors, RO3280 and GSK461364, to the human serum albumin (HSA) protein as well as the protonation equilibria of both compounds have been studied combining absorbance and fluorescence spectroscopy experiments together with density fu...

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Detalles Bibliográficos
Autores principales: Fernández-Sainz, Jesús, Pacheco-Liñán, Pedro J., Ripoll, Consuelo, González-Fuentes, Joaquín, Albaladejo, José, Bravo, Iván, Garzón-Ruiz, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997069/
https://www.ncbi.nlm.nih.gov/pubmed/36812406
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997069/
https://www.ncbi.nlm.nih.gov/pubmed/36812406
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00849

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