Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo

Cancer immunotherapy has demonstrated great promise with several checkpoint inhibitors being approved as the first-line therapy for some types of cancer, and new engineered cytokines such as Neo2/15 now being evaluated in many studies. In this work, we designed antibody-cytokine chimera (ACC) scaffo...

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Detalles Bibliográficos
Autores principales: Tursi, Nicholas J., Xu, Ziyang, Helble, Michaela, Walker, Susanne, Liaw, Kevin, Chokkalingam, Neethu, Kannan, Toshitha, Wu, Yuanhan, Tello-Ruiz, Edgar, Park, Daniel H., Zhu, Xizhou, Wise, Megan C., Smith, Trevor R. F., Majumdar, Sonali, Kossenkov, Andrew, Kulp, Daniel W., Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997082/
https://www.ncbi.nlm.nih.gov/pubmed/36911698
http://dx.doi.org/10.3389/fimmu.2023.1072810

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