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Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults
We investigated how the aging brain copes with acoustic and syntactic challenges during spoken language comprehension. Thirty-eight healthy adults aged 54 – 80 years (M = 66 years) participated in an fMRI experiment wherein listeners indicated the gender of an agent in short spoken sentences that va...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997128/ https://www.ncbi.nlm.nih.gov/pubmed/36908889 http://dx.doi.org/10.1016/j.nbas.2022.100051 |
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author | Lee, Yune Sang Rogers, Chad S. Grossman, Murray Wingfield, Arthur Peelle, Jonathan E. |
author_facet | Lee, Yune Sang Rogers, Chad S. Grossman, Murray Wingfield, Arthur Peelle, Jonathan E. |
author_sort | Lee, Yune Sang |
collection | PubMed |
description | We investigated how the aging brain copes with acoustic and syntactic challenges during spoken language comprehension. Thirty-eight healthy adults aged 54 – 80 years (M = 66 years) participated in an fMRI experiment wherein listeners indicated the gender of an agent in short spoken sentences that varied in syntactic complexity (object-relative vs subject-relative center-embedded clause structures) and acoustic richness (high vs low spectral detail, but all intelligible). We found widespread activity throughout a bilateral frontotemporal network during successful sentence comprehension. Consistent with prior reports, bilateral inferior frontal gyrus and left posterior superior temporal gyrus were more active in response to object-relative sentences than to subject-relative sentences. Moreover, several regions were significantly correlated with individual differences in task performance: Activity in right frontoparietal cortex and left cerebellum (Crus I & II) showed a negative correlation with overall comprehension. By contrast, left frontotemporal areas and right cerebellum (Lobule VII) showed a negative correlation with accuracy specifically for syntactically complex sentences. In addition, laterality analyses confirmed a lack of hemispheric lateralization in activity evoked by sentence stimuli in older adults. Importantly, we found different hemispheric roles, with a left-lateralized core language network supporting syntactic operations, and right-hemisphere regions coming into play to aid in general cognitive demands during spoken sentence processing. Together our findings support the view that high levels of language comprehension in older adults are maintained by a close interplay between a core left hemisphere language network and additional neural resources in the contralateral hemisphere. |
format | Online Article Text |
id | pubmed-9997128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99971282023-03-09 Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults Lee, Yune Sang Rogers, Chad S. Grossman, Murray Wingfield, Arthur Peelle, Jonathan E. Aging Brain Article We investigated how the aging brain copes with acoustic and syntactic challenges during spoken language comprehension. Thirty-eight healthy adults aged 54 – 80 years (M = 66 years) participated in an fMRI experiment wherein listeners indicated the gender of an agent in short spoken sentences that varied in syntactic complexity (object-relative vs subject-relative center-embedded clause structures) and acoustic richness (high vs low spectral detail, but all intelligible). We found widespread activity throughout a bilateral frontotemporal network during successful sentence comprehension. Consistent with prior reports, bilateral inferior frontal gyrus and left posterior superior temporal gyrus were more active in response to object-relative sentences than to subject-relative sentences. Moreover, several regions were significantly correlated with individual differences in task performance: Activity in right frontoparietal cortex and left cerebellum (Crus I & II) showed a negative correlation with overall comprehension. By contrast, left frontotemporal areas and right cerebellum (Lobule VII) showed a negative correlation with accuracy specifically for syntactically complex sentences. In addition, laterality analyses confirmed a lack of hemispheric lateralization in activity evoked by sentence stimuli in older adults. Importantly, we found different hemispheric roles, with a left-lateralized core language network supporting syntactic operations, and right-hemisphere regions coming into play to aid in general cognitive demands during spoken sentence processing. Together our findings support the view that high levels of language comprehension in older adults are maintained by a close interplay between a core left hemisphere language network and additional neural resources in the contralateral hemisphere. Elsevier 2022-08-27 /pmc/articles/PMC9997128/ /pubmed/36908889 http://dx.doi.org/10.1016/j.nbas.2022.100051 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Lee, Yune Sang Rogers, Chad S. Grossman, Murray Wingfield, Arthur Peelle, Jonathan E. Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title | Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title_full | Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title_fullStr | Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title_full_unstemmed | Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title_short | Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
title_sort | hemispheric dissociations in regions supporting auditory sentence comprehension in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997128/ https://www.ncbi.nlm.nih.gov/pubmed/36908889 http://dx.doi.org/10.1016/j.nbas.2022.100051 |
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