Sidestepping SHP2 inhibition

Allosteric SHP2 inhibitors are a novel class of compounds that target hyperactive Ras/Mitogen Activated Protein Kinase (MAPK) signaling. In this issue of JEM, Wei et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221563) report a genome-wide CRISPR/Cas9 knockout screen that uncovered novel me...

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Detalles Bibliográficos
Autores principales: Popescu, Bogdan, Shannon, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997206/
https://www.ncbi.nlm.nih.gov/pubmed/36880733
http://dx.doi.org/10.1084/jem.20230082
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author Popescu, Bogdan
Shannon, Kevin
author_facet Popescu, Bogdan
Shannon, Kevin
author_sort Popescu, Bogdan
collection PubMed
description Allosteric SHP2 inhibitors are a novel class of compounds that target hyperactive Ras/Mitogen Activated Protein Kinase (MAPK) signaling. In this issue of JEM, Wei et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221563) report a genome-wide CRISPR/Cas9 knockout screen that uncovered novel mechanisms of adaptive resistance to pharmacologic inhibition of SHP2.
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spelling pubmed-99972062023-09-03 Sidestepping SHP2 inhibition Popescu, Bogdan Shannon, Kevin J Exp Med Insights Allosteric SHP2 inhibitors are a novel class of compounds that target hyperactive Ras/Mitogen Activated Protein Kinase (MAPK) signaling. In this issue of JEM, Wei et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20221563) report a genome-wide CRISPR/Cas9 knockout screen that uncovered novel mechanisms of adaptive resistance to pharmacologic inhibition of SHP2. Rockefeller University Press 2023-03-03 /pmc/articles/PMC9997206/ /pubmed/36880733 http://dx.doi.org/10.1084/jem.20230082 Text en © 2023 Popescu and Shannon https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Popescu, Bogdan
Shannon, Kevin
Sidestepping SHP2 inhibition
title Sidestepping SHP2 inhibition
title_full Sidestepping SHP2 inhibition
title_fullStr Sidestepping SHP2 inhibition
title_full_unstemmed Sidestepping SHP2 inhibition
title_short Sidestepping SHP2 inhibition
title_sort sidestepping shp2 inhibition
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997206/
https://www.ncbi.nlm.nih.gov/pubmed/36880733
http://dx.doi.org/10.1084/jem.20230082
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