Macrophages and bone metastasis

In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med. https://doi.org/10.1084/jem.20221007) have broad implicatio...

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Detalles Bibliográficos
Autores principales: Di Mitri, Diletta, Conforti, Fabio, Mantovani, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997208/
https://www.ncbi.nlm.nih.gov/pubmed/36828392
http://dx.doi.org/10.1084/jem.20222188
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author Di Mitri, Diletta
Conforti, Fabio
Mantovani, Alberto
author_facet Di Mitri, Diletta
Conforti, Fabio
Mantovani, Alberto
author_sort Di Mitri, Diletta
collection PubMed
description In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med. https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.
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spelling pubmed-99972082023-08-24 Macrophages and bone metastasis Di Mitri, Diletta Conforti, Fabio Mantovani, Alberto J Exp Med Insights In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med. https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity. Rockefeller University Press 2023-02-24 /pmc/articles/PMC9997208/ /pubmed/36828392 http://dx.doi.org/10.1084/jem.20222188 Text en © 2023 Di Mitri et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Di Mitri, Diletta
Conforti, Fabio
Mantovani, Alberto
Macrophages and bone metastasis
title Macrophages and bone metastasis
title_full Macrophages and bone metastasis
title_fullStr Macrophages and bone metastasis
title_full_unstemmed Macrophages and bone metastasis
title_short Macrophages and bone metastasis
title_sort macrophages and bone metastasis
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997208/
https://www.ncbi.nlm.nih.gov/pubmed/36828392
http://dx.doi.org/10.1084/jem.20222188
work_keys_str_mv AT dimitridiletta macrophagesandbonemetastasis
AT confortifabio macrophagesandbonemetastasis
AT mantovanialberto macrophagesandbonemetastasis

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