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Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections

Reported neuro-modulation schemes in the literature are typically classified as closed-loop or open-loop. A novel group of recently developed neuro-modulation devices may be better described as a neural bypass, which attempts to transmit neural data from one location of the nervous system to another...

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Autores principales: Zuccaroli, Isabella, Lucke-Wold, Brandon, Palla, Adhith, Eremiev, Alexander, Sorrentino, Zachary, Zakare-Fagbamila, Rasheedat, McNulty, Jack, Christie, Carlton, Chandra, Vyshak, Mampre, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997488/
https://www.ncbi.nlm.nih.gov/pubmed/36908763
http://dx.doi.org/10.21926/obm.neurobiol.2301158
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author Zuccaroli, Isabella
Lucke-Wold, Brandon
Palla, Adhith
Eremiev, Alexander
Sorrentino, Zachary
Zakare-Fagbamila, Rasheedat
McNulty, Jack
Christie, Carlton
Chandra, Vyshak
Mampre, David
author_facet Zuccaroli, Isabella
Lucke-Wold, Brandon
Palla, Adhith
Eremiev, Alexander
Sorrentino, Zachary
Zakare-Fagbamila, Rasheedat
McNulty, Jack
Christie, Carlton
Chandra, Vyshak
Mampre, David
author_sort Zuccaroli, Isabella
collection PubMed
description Reported neuro-modulation schemes in the literature are typically classified as closed-loop or open-loop. A novel group of recently developed neuro-modulation devices may be better described as a neural bypass, which attempts to transmit neural data from one location of the nervous system to another. The most common form of neural bypasses in the literature utilize EEG recordings of cortical information paired with functional electrical stimulation for effector muscle output, most commonly for assistive applications and rehabilitation in spinal cord injury or stroke. Other neural bypass locations that have also been described, or may soon be in development, include cortical-spinal bypasses, cortical-cortical bypasses, autonomic bypasses, peripheral-central bypasses, and inter-subject bypasses. The most common recording devices include EEG, ECoG, and microelectrode arrays, while stimulation devices include both invasive and noninvasive electrodes. Several devices are in development to improve the temporal and spatial resolution and biocompatibility for neuronal recording and stimulation. A major barrier to entry includes neuroplasticity and current decoding mechanisms that regularly require retraining. Neural bypasses are a unique class of neuro-modulation. Continued advancement of neural recording and stimulating devices with high spatial and temporal resolution, combined with decoding mechanisms uninhibited by neuroplasticity, can expand the therapeutic capability of neural bypassing. Overall, neural bypasses are a promising modality to improve the treatment of common neurologic disorders, including stroke, spinal cord injury, peripheral nerve injury, brain injury and more.
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spelling pubmed-99974882023-03-09 Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections Zuccaroli, Isabella Lucke-Wold, Brandon Palla, Adhith Eremiev, Alexander Sorrentino, Zachary Zakare-Fagbamila, Rasheedat McNulty, Jack Christie, Carlton Chandra, Vyshak Mampre, David OBM Neurobiol Article Reported neuro-modulation schemes in the literature are typically classified as closed-loop or open-loop. A novel group of recently developed neuro-modulation devices may be better described as a neural bypass, which attempts to transmit neural data from one location of the nervous system to another. The most common form of neural bypasses in the literature utilize EEG recordings of cortical information paired with functional electrical stimulation for effector muscle output, most commonly for assistive applications and rehabilitation in spinal cord injury or stroke. Other neural bypass locations that have also been described, or may soon be in development, include cortical-spinal bypasses, cortical-cortical bypasses, autonomic bypasses, peripheral-central bypasses, and inter-subject bypasses. The most common recording devices include EEG, ECoG, and microelectrode arrays, while stimulation devices include both invasive and noninvasive electrodes. Several devices are in development to improve the temporal and spatial resolution and biocompatibility for neuronal recording and stimulation. A major barrier to entry includes neuroplasticity and current decoding mechanisms that regularly require retraining. Neural bypasses are a unique class of neuro-modulation. Continued advancement of neural recording and stimulating devices with high spatial and temporal resolution, combined with decoding mechanisms uninhibited by neuroplasticity, can expand the therapeutic capability of neural bypassing. Overall, neural bypasses are a promising modality to improve the treatment of common neurologic disorders, including stroke, spinal cord injury, peripheral nerve injury, brain injury and more. 2023 2023-02-22 /pmc/articles/PMC9997488/ /pubmed/36908763 http://dx.doi.org/10.21926/obm.neurobiol.2301158 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.
spellingShingle Article
Zuccaroli, Isabella
Lucke-Wold, Brandon
Palla, Adhith
Eremiev, Alexander
Sorrentino, Zachary
Zakare-Fagbamila, Rasheedat
McNulty, Jack
Christie, Carlton
Chandra, Vyshak
Mampre, David
Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title_full Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title_fullStr Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title_full_unstemmed Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title_short Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections
title_sort neural bypasses: literature review and future directions in developing artificial neural connections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997488/
https://www.ncbi.nlm.nih.gov/pubmed/36908763
http://dx.doi.org/10.21926/obm.neurobiol.2301158
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