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Progressive nodule-like lesions on bilateral lower limbs

Pancreatic panniculitis is a rare disease characterized by subcutaneous fat necrosis. It could be the result of an associated pancreatic tumor. Herein, we reported a 63-year-old man who presented with progressive bilateral lower limb edema accompanied with nodule-like lesions for 1 month. His serum...

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Detalles Bibliográficos
Autores principales: Yang, FA, Cheng, KS, Chou, JW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997608/
https://www.ncbi.nlm.nih.gov/pubmed/36537394
http://dx.doi.org/10.4103/jpgm.jpgm_136_22
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author Yang, FA
Cheng, KS
Chou, JW
author_facet Yang, FA
Cheng, KS
Chou, JW
author_sort Yang, FA
collection PubMed
description Pancreatic panniculitis is a rare disease characterized by subcutaneous fat necrosis. It could be the result of an associated pancreatic tumor. Herein, we reported a 63-year-old man who presented with progressive bilateral lower limb edema accompanied with nodule-like lesions for 1 month. His serum lipase was 3,927 U/L (normal, 0–160 U/L). Histopathology of the skin specimen revealed lobular panniculitis, favoring a diagnosis of pancreatic panniculitis. Abdominal computed tomography (CT) scan with contrast showed a huge mass in his left upper quadrant. Endoscopic ultrasound showed a mixed echoic tumor, measuring 11.9 × 7.8 cm in dimensions, originating from the pancreatic tail. Biopsy performed via an endoscopic ultrasound showed a poorly differentiated acinar cell carcinoma. Because of the unresectable status of the tumor, the patient underwent chemotherapy with paclitaxel and gemcitabine. After chemotherapy, his skin lesions improved progressively. It is important to treat pancreatic panniculitis with its underlying pancreatic disease.
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spelling pubmed-99976082023-03-10 Progressive nodule-like lesions on bilateral lower limbs Yang, FA Cheng, KS Chou, JW J Postgrad Med Case Report Pancreatic panniculitis is a rare disease characterized by subcutaneous fat necrosis. It could be the result of an associated pancreatic tumor. Herein, we reported a 63-year-old man who presented with progressive bilateral lower limb edema accompanied with nodule-like lesions for 1 month. His serum lipase was 3,927 U/L (normal, 0–160 U/L). Histopathology of the skin specimen revealed lobular panniculitis, favoring a diagnosis of pancreatic panniculitis. Abdominal computed tomography (CT) scan with contrast showed a huge mass in his left upper quadrant. Endoscopic ultrasound showed a mixed echoic tumor, measuring 11.9 × 7.8 cm in dimensions, originating from the pancreatic tail. Biopsy performed via an endoscopic ultrasound showed a poorly differentiated acinar cell carcinoma. Because of the unresectable status of the tumor, the patient underwent chemotherapy with paclitaxel and gemcitabine. After chemotherapy, his skin lesions improved progressively. It is important to treat pancreatic panniculitis with its underlying pancreatic disease. Wolters Kluwer - Medknow 2023 2022-12-19 /pmc/articles/PMC9997608/ /pubmed/36537394 http://dx.doi.org/10.4103/jpgm.jpgm_136_22 Text en Copyright: © 2022 Journal of Postgraduate Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Yang, FA
Cheng, KS
Chou, JW
Progressive nodule-like lesions on bilateral lower limbs
title Progressive nodule-like lesions on bilateral lower limbs
title_full Progressive nodule-like lesions on bilateral lower limbs
title_fullStr Progressive nodule-like lesions on bilateral lower limbs
title_full_unstemmed Progressive nodule-like lesions on bilateral lower limbs
title_short Progressive nodule-like lesions on bilateral lower limbs
title_sort progressive nodule-like lesions on bilateral lower limbs
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997608/
https://www.ncbi.nlm.nih.gov/pubmed/36537394
http://dx.doi.org/10.4103/jpgm.jpgm_136_22
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