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High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer

We have previously reported that patients with high Syndecan 1 (SDC1) expression in colorectal cancer (CRC) cells have a favorable prognosis, and we also found that stromal cells showed upregulation of SDC1, but the clinical significance is unclear. The expression of SDC1 in the stroma cells was ass...

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Autores principales: Li, Zhejie, He, Shujin, Liu, Jianli, Zhi, Xiao, Yang, Lili, Zhang, Junjun, Zhao, Ran, Zhang, Renya, Li, Lei, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997619/
https://www.ncbi.nlm.nih.gov/pubmed/36730554
http://dx.doi.org/10.1097/CAD.0000000000001441
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author Li, Zhejie
He, Shujin
Liu, Jianli
Zhi, Xiao
Yang, Lili
Zhang, Junjun
Zhao, Ran
Zhang, Renya
Li, Lei
Wang, Wei
author_facet Li, Zhejie
He, Shujin
Liu, Jianli
Zhi, Xiao
Yang, Lili
Zhang, Junjun
Zhao, Ran
Zhang, Renya
Li, Lei
Wang, Wei
author_sort Li, Zhejie
collection PubMed
description We have previously reported that patients with high Syndecan 1 (SDC1) expression in colorectal cancer (CRC) cells have a favorable prognosis, and we also found that stromal cells showed upregulation of SDC1, but the clinical significance is unclear. The expression of SDC1 in the stroma cells was assessed by immunohistochemistry using a tissue microarray comprising representative cores from 513 CRC patients. The correlation between the expression of SDC1 in the stroma cells and the clinicopathological features of patients was analyzed. The data showed that the expression of SDC1 in the stroma cells was correlated with the degree of differentiation (P = 0.012) and tumor location (up or down) (P = 0.005). Also, CRCs patients with high expression of SDC1 in the stromal cells have a good prognosis (P = 0.0369). Accumulating evidence indicates that SDC1, whether in tumor cells or stromal cells, plays a tumor-suppressor role in CRCs.
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spelling pubmed-99976192023-03-09 High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer Li, Zhejie He, Shujin Liu, Jianli Zhi, Xiao Yang, Lili Zhang, Junjun Zhao, Ran Zhang, Renya Li, Lei Wang, Wei Anticancer Drugs Pre-Clinical Reports We have previously reported that patients with high Syndecan 1 (SDC1) expression in colorectal cancer (CRC) cells have a favorable prognosis, and we also found that stromal cells showed upregulation of SDC1, but the clinical significance is unclear. The expression of SDC1 in the stroma cells was assessed by immunohistochemistry using a tissue microarray comprising representative cores from 513 CRC patients. The correlation between the expression of SDC1 in the stroma cells and the clinicopathological features of patients was analyzed. The data showed that the expression of SDC1 in the stroma cells was correlated with the degree of differentiation (P = 0.012) and tumor location (up or down) (P = 0.005). Also, CRCs patients with high expression of SDC1 in the stromal cells have a good prognosis (P = 0.0369). Accumulating evidence indicates that SDC1, whether in tumor cells or stromal cells, plays a tumor-suppressor role in CRCs. Lippincott Williams & Wilkins 2023-04 2022-11-17 /pmc/articles/PMC9997619/ /pubmed/36730554 http://dx.doi.org/10.1097/CAD.0000000000001441 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Pre-Clinical Reports
Li, Zhejie
He, Shujin
Liu, Jianli
Zhi, Xiao
Yang, Lili
Zhang, Junjun
Zhao, Ran
Zhang, Renya
Li, Lei
Wang, Wei
High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title_full High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title_fullStr High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title_full_unstemmed High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title_short High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer
title_sort high expression of sdc1 in stromal cells is associated with good prognosis in colorectal cancer
topic Pre-Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997619/
https://www.ncbi.nlm.nih.gov/pubmed/36730554
http://dx.doi.org/10.1097/CAD.0000000000001441
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