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Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1

We previously reported that glycosylphosphatidylinositol (GPI) biosynthesis is upregulated when endoplasmic reticulum–associated degradation (ERAD) is defective; however, the underlying mechanistic basis remains unclear. Based on a genome-wide CRISPR–Cas9 screen, we show that a widely expressed GPI-...

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Detalles Bibliográficos
Autores principales:	Liu, Yi-Shi, Wang, Yicheng, Zhou, Xiaoman, Zhang, Linpei, Yang, Ganglong, Gao, Xiao-Dong, Murakami, Yoshiko, Fujita, Morihisa, Kinoshita, Taroh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997660/ https://www.ncbi.nlm.nih.gov/pubmed/36828365 http://dx.doi.org/10.1083/jcb.202208159

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