Cargando…

Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review

Allergic rhinitis is prone to recurrence, and clinical treatments focus on control symptoms; however there is no radical cure. Our aim was to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of Tongqiao Huoxue decoction against alle...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Fang, Wu, Jiani, Shen, Qu, Chen, Zhiling, Qiao, Zukang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997813/
https://www.ncbi.nlm.nih.gov/pubmed/36897696
http://dx.doi.org/10.1097/MD.0000000000033190
_version_ 1784903333878693888
author Zhang, Fang
Wu, Jiani
Shen, Qu
Chen, Zhiling
Qiao, Zukang
author_facet Zhang, Fang
Wu, Jiani
Shen, Qu
Chen, Zhiling
Qiao, Zukang
author_sort Zhang, Fang
collection PubMed
description Allergic rhinitis is prone to recurrence, and clinical treatments focus on control symptoms; however there is no radical cure. Our aim was to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of Tongqiao Huoxue decoction against allergic rhinitis. First, the chemical components and target genes of Tongqiao Huoxue decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology database. Similarly, allergic rhinitis targets were screened using online Mendelian Inheritance In Man and GeneCards database. Then, all potential targets of Tongqiao Huoxue decoction in the treatment of allergic rhinitis were identified, the Venn diagram was portrayed using R software, and protein-protein interaction network was built using String. The hub genes were analyzed using enrichment analyses. Finally, molecular docking was used to verify the reliability of the key gene prediction. The core targets for Tongqiao Huoxue decoction to improve allergic rhinitis were AKT1, TP53, IL6, and so on. The enrichment analysis results showed that Tongqiao Huoxue decoction treatment in allergic rhinitis might be involved in the AGE-RAGE signaling pathway and fluid shear stress and atherosclerosis pathway. The molecular docking verification indicated that its ingredients bound well to the core targets of allergic rhinitis, and stigmasterol’s docking ability with TNF (−12.73 kcal/mol) is particularly prominent. Based on these findings, it may be deduced that stigmasterol treated allergic rhinitis by acting on TNF targets. But, this conclusion needs to be confirmed by further in vitro and in vivo trials.
format Online
Article
Text
id pubmed-9997813
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-99978132023-03-10 Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review Zhang, Fang Wu, Jiani Shen, Qu Chen, Zhiling Qiao, Zukang Medicine (Baltimore) 4200 Allergic rhinitis is prone to recurrence, and clinical treatments focus on control symptoms; however there is no radical cure. Our aim was to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of Tongqiao Huoxue decoction against allergic rhinitis. First, the chemical components and target genes of Tongqiao Huoxue decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology database. Similarly, allergic rhinitis targets were screened using online Mendelian Inheritance In Man and GeneCards database. Then, all potential targets of Tongqiao Huoxue decoction in the treatment of allergic rhinitis were identified, the Venn diagram was portrayed using R software, and protein-protein interaction network was built using String. The hub genes were analyzed using enrichment analyses. Finally, molecular docking was used to verify the reliability of the key gene prediction. The core targets for Tongqiao Huoxue decoction to improve allergic rhinitis were AKT1, TP53, IL6, and so on. The enrichment analysis results showed that Tongqiao Huoxue decoction treatment in allergic rhinitis might be involved in the AGE-RAGE signaling pathway and fluid shear stress and atherosclerosis pathway. The molecular docking verification indicated that its ingredients bound well to the core targets of allergic rhinitis, and stigmasterol’s docking ability with TNF (−12.73 kcal/mol) is particularly prominent. Based on these findings, it may be deduced that stigmasterol treated allergic rhinitis by acting on TNF targets. But, this conclusion needs to be confirmed by further in vitro and in vivo trials. Lippincott Williams & Wilkins 2023-03-10 /pmc/articles/PMC9997813/ /pubmed/36897696 http://dx.doi.org/10.1097/MD.0000000000033190 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4200
Zhang, Fang
Wu, Jiani
Shen, Qu
Chen, Zhiling
Qiao, Zukang
Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title_full Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title_fullStr Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title_full_unstemmed Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title_short Investigating the mechanism of Tongqiao Huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: A review
title_sort investigating the mechanism of tongqiao huoxue decotion in the treatment of allergic rhinitis based on network pharmacology and molecular docking: a review
topic 4200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997813/
https://www.ncbi.nlm.nih.gov/pubmed/36897696
http://dx.doi.org/10.1097/MD.0000000000033190
work_keys_str_mv AT zhangfang investigatingthemechanismoftongqiaohuoxuedecotioninthetreatmentofallergicrhinitisbasedonnetworkpharmacologyandmoleculardockingareview
AT wujiani investigatingthemechanismoftongqiaohuoxuedecotioninthetreatmentofallergicrhinitisbasedonnetworkpharmacologyandmoleculardockingareview
AT shenqu investigatingthemechanismoftongqiaohuoxuedecotioninthetreatmentofallergicrhinitisbasedonnetworkpharmacologyandmoleculardockingareview
AT chenzhiling investigatingthemechanismoftongqiaohuoxuedecotioninthetreatmentofallergicrhinitisbasedonnetworkpharmacologyandmoleculardockingareview
AT qiaozukang investigatingthemechanismoftongqiaohuoxuedecotioninthetreatmentofallergicrhinitisbasedonnetworkpharmacologyandmoleculardockingareview