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Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach

A new semisynthetic derivative of the natural alkaloid, theobromine, has been designed as a lead antiangiogenic compound targeting the EGFR protein. The designed compound is an (m-tolyl)acetamide theobromine derivative, (T-1-MTA). Molecular Docking studies have shown a great potential for T-1-MTA to...

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Detalles Bibliográficos
Autores principales:	Eissa, Ibrahim H., Yousef, Reda G., Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Alesawy, Mohamed S., Elkady, Hazem, Metwaly, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997933/ https://www.ncbi.nlm.nih.gov/pubmed/36893122 http://dx.doi.org/10.1371/journal.pone.0282586

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