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Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury

The ability to navigate is supported by a wide network of brain areas which are particularly vulnerable to disruption brain injury, including traumatic brain injury (TBI). Wayfinding and the ability to orient back to the direction you have recently come (path integration) may likely be impacted in d...

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Autores principales: Seton, Caroline, Coutrot, Antoine, Hornberger, Michael, Spiers, Hugo J., Knight, Rebecca, Whyatt, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997943/
https://www.ncbi.nlm.nih.gov/pubmed/36893089
http://dx.doi.org/10.1371/journal.pone.0282255
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author Seton, Caroline
Coutrot, Antoine
Hornberger, Michael
Spiers, Hugo J.
Knight, Rebecca
Whyatt, Caroline
author_facet Seton, Caroline
Coutrot, Antoine
Hornberger, Michael
Spiers, Hugo J.
Knight, Rebecca
Whyatt, Caroline
author_sort Seton, Caroline
collection PubMed
description The ability to navigate is supported by a wide network of brain areas which are particularly vulnerable to disruption brain injury, including traumatic brain injury (TBI). Wayfinding and the ability to orient back to the direction you have recently come (path integration) may likely be impacted in daily life but have so far not been tested with patients with TBI. Here, we assessed spatial navigation in thirty–eight participants, fifteen of whom had a history of TBI, and twenty–three control participants. Self-estimated spatial navigation ability was assessed using the Santa Barbara Sense of Direction (SBSOD) scale. No significant difference between TBI patients and a control group was identified. Rather, results indicated that both participant groups demonstrated ‘good’ self–inferred spatial navigational ability on the SBSOD scale. Objective navigation ability was tested via the virtual mobile app test Sea Hero Quest (SHQ), which has been shown to predict real–world navigation difficulties and assesses (a) wayfinding across several environments and (b) path integration. Compared to a sub-sample of 13 control participants, a matched subsample of 10 TBI patients demonstrated generally poorer performance on all wayfinding environments tested. Further analysis revealed that TBI participants consistently spent a shorter duration viewing a map prior to navigating to goals. Patients showed mixed performance on the path integration task, with poor performance evident when proximal cues were absent. Our results provide preliminary evidence that TBI impacts both wayfinding and, to some extent, path integration. The findings suggest long–lasting clinical difficulties experienced in TBI patients affect both wayfinding and to some degree path integration ability.
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spelling pubmed-99979432023-03-10 Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury Seton, Caroline Coutrot, Antoine Hornberger, Michael Spiers, Hugo J. Knight, Rebecca Whyatt, Caroline PLoS One Research Article The ability to navigate is supported by a wide network of brain areas which are particularly vulnerable to disruption brain injury, including traumatic brain injury (TBI). Wayfinding and the ability to orient back to the direction you have recently come (path integration) may likely be impacted in daily life but have so far not been tested with patients with TBI. Here, we assessed spatial navigation in thirty–eight participants, fifteen of whom had a history of TBI, and twenty–three control participants. Self-estimated spatial navigation ability was assessed using the Santa Barbara Sense of Direction (SBSOD) scale. No significant difference between TBI patients and a control group was identified. Rather, results indicated that both participant groups demonstrated ‘good’ self–inferred spatial navigational ability on the SBSOD scale. Objective navigation ability was tested via the virtual mobile app test Sea Hero Quest (SHQ), which has been shown to predict real–world navigation difficulties and assesses (a) wayfinding across several environments and (b) path integration. Compared to a sub-sample of 13 control participants, a matched subsample of 10 TBI patients demonstrated generally poorer performance on all wayfinding environments tested. Further analysis revealed that TBI participants consistently spent a shorter duration viewing a map prior to navigating to goals. Patients showed mixed performance on the path integration task, with poor performance evident when proximal cues were absent. Our results provide preliminary evidence that TBI impacts both wayfinding and, to some extent, path integration. The findings suggest long–lasting clinical difficulties experienced in TBI patients affect both wayfinding and to some degree path integration ability. Public Library of Science 2023-03-09 /pmc/articles/PMC9997943/ /pubmed/36893089 http://dx.doi.org/10.1371/journal.pone.0282255 Text en © 2023 Seton et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Seton, Caroline
Coutrot, Antoine
Hornberger, Michael
Spiers, Hugo J.
Knight, Rebecca
Whyatt, Caroline
Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title_full Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title_fullStr Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title_full_unstemmed Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title_short Wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
title_sort wayfinding and path integration deficits detected using a virtual reality mobile app in patients with traumatic brain injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997943/
https://www.ncbi.nlm.nih.gov/pubmed/36893089
http://dx.doi.org/10.1371/journal.pone.0282255
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