SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown. Based on a screening panel, IL-18...

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Detalles Bibliográficos
Autores principales: Liang, Shuxin, Bao, Changlei, Yang, Zi, Liu, Shiyun, Sun, Yanan, Cao, Weitao, Wang, Ting, Schwantes-An, Tae-Hwi, Choy, John S., Naidu, Samisubbu, Luo, Ang, Yin, Wenguang, Black, Stephen M., Wang, Jian, Ran, Pixin, Desai, Ankit A., Tang, Haiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998025/
https://www.ncbi.nlm.nih.gov/pubmed/36894537
http://dx.doi.org/10.1038/s41392-023-01368-w

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