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Bioengineered extracellular vesicles: future of precision medicine for sepsis
Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high heterogeneity of sepsis hinder the possibility to treat all patients with the same protocol, requiring personalized management. The versatili...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998145/ https://www.ncbi.nlm.nih.gov/pubmed/36894763 http://dx.doi.org/10.1186/s40635-023-00491-w |
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author | Areny-Balagueró, Aina Solé-Porta, Anna Camprubí-Rimblas, Marta Campaña-Duel, Elena Ceccato, Adrián Roig, Anna Closa, Daniel Artigas, Antonio |
author_facet | Areny-Balagueró, Aina Solé-Porta, Anna Camprubí-Rimblas, Marta Campaña-Duel, Elena Ceccato, Adrián Roig, Anna Closa, Daniel Artigas, Antonio |
author_sort | Areny-Balagueró, Aina |
collection | PubMed |
description | Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high heterogeneity of sepsis hinder the possibility to treat all patients with the same protocol, requiring personalized management. The versatility of extracellular vesicles (EVs) and their contribution to sepsis progression bring along promises for one-to-one tailoring sepsis treatment and diagnosis. In this article, we critically review the endogenous role of EVs in sepsis progression and how current advancements have improved EVs-based therapies toward their translational future clinical application, with innovative strategies to enhance EVs effect. More complex approaches, including hybrid and fully synthetic nanocarriers that mimic EVs, are also discussed. Several pre-clinical and clinical studies are examined through the review to offer a general outlook of the current and future perspectives of EV-based sepsis diagnosis and treatment. |
format | Online Article Text |
id | pubmed-9998145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-99981452023-03-10 Bioengineered extracellular vesicles: future of precision medicine for sepsis Areny-Balagueró, Aina Solé-Porta, Anna Camprubí-Rimblas, Marta Campaña-Duel, Elena Ceccato, Adrián Roig, Anna Closa, Daniel Artigas, Antonio Intensive Care Med Exp Reviews Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high heterogeneity of sepsis hinder the possibility to treat all patients with the same protocol, requiring personalized management. The versatility of extracellular vesicles (EVs) and their contribution to sepsis progression bring along promises for one-to-one tailoring sepsis treatment and diagnosis. In this article, we critically review the endogenous role of EVs in sepsis progression and how current advancements have improved EVs-based therapies toward their translational future clinical application, with innovative strategies to enhance EVs effect. More complex approaches, including hybrid and fully synthetic nanocarriers that mimic EVs, are also discussed. Several pre-clinical and clinical studies are examined through the review to offer a general outlook of the current and future perspectives of EV-based sepsis diagnosis and treatment. Springer International Publishing 2023-03-10 /pmc/articles/PMC9998145/ /pubmed/36894763 http://dx.doi.org/10.1186/s40635-023-00491-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Reviews Areny-Balagueró, Aina Solé-Porta, Anna Camprubí-Rimblas, Marta Campaña-Duel, Elena Ceccato, Adrián Roig, Anna Closa, Daniel Artigas, Antonio Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title | Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title_full | Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title_fullStr | Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title_full_unstemmed | Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title_short | Bioengineered extracellular vesicles: future of precision medicine for sepsis |
title_sort | bioengineered extracellular vesicles: future of precision medicine for sepsis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998145/ https://www.ncbi.nlm.nih.gov/pubmed/36894763 http://dx.doi.org/10.1186/s40635-023-00491-w |
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