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Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC)
Background Spread through air spaces (STAS) is a recently described route of tumor invasion associated with poor prognosis in primary lung cancer. Aim of this study was to investigate the presence of STAS and to assess its prognostic significance in patients undergoing pulmonary metastasectomy (PM)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag KG
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998148/ https://www.ncbi.nlm.nih.gov/pubmed/36257546 http://dx.doi.org/10.1055/s-0042-1757632 |
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author | Haj Khalaf, Mohamed Anwar Sirbu, Horia Hartmann, Arndt Agaimy, Abbas Dudek, Wojciech Higaze, Mostafa Rieker, Ralf |
author_facet | Haj Khalaf, Mohamed Anwar Sirbu, Horia Hartmann, Arndt Agaimy, Abbas Dudek, Wojciech Higaze, Mostafa Rieker, Ralf |
author_sort | Haj Khalaf, Mohamed Anwar |
collection | PubMed |
description | Background Spread through air spaces (STAS) is a recently described route of tumor invasion associated with poor prognosis in primary lung cancer. Aim of this study was to investigate the presence of STAS and to assess its prognostic significance in patients undergoing pulmonary metastasectomy (PM) for solitary metastases from colorectal cancer (CRC). Materials and Methods All 49 CRC patients (30 male and 19 female, median age 66 years) who underwent PM between January 2008 and December 2015 were retrospectively analyzed. Results STAS was identified in 26.5% ( n = 13) of resected specimens. Location of pulmonary lesions (central vs. peripheral) was assessed based on the available computed tomography imaging ( n = 47, 96%). STAS was detected in all five patients with central metastases (100%) versus 7 of 42 (17%) with peripheral metastases ( p = 0.0001). Locoregional recurrence occurred in STAS-positive patients ( n = 4 of 13 vs. n = 0 of 36), all STAS-negative patients remained recurrence-free ( p = 0.003). Median number of alveoli with STAS involvement was four (range from 2 to 9). There was statistically positive relationship between the number of alveoli invaded with STAS and locoregional recurrence of metastases ( p = 0.0001). The presence of STAS is not a factor affecting the 5-year overall survival rate ( p = 0.6651). Conclusion We identified STAS as a frequent finding in resected CRC lung metastases and found insignificant association with outcome. |
format | Online Article Text |
id | pubmed-9998148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-99981482023-03-10 Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) Haj Khalaf, Mohamed Anwar Sirbu, Horia Hartmann, Arndt Agaimy, Abbas Dudek, Wojciech Higaze, Mostafa Rieker, Ralf Thorac Cardiovasc Surg Background Spread through air spaces (STAS) is a recently described route of tumor invasion associated with poor prognosis in primary lung cancer. Aim of this study was to investigate the presence of STAS and to assess its prognostic significance in patients undergoing pulmonary metastasectomy (PM) for solitary metastases from colorectal cancer (CRC). Materials and Methods All 49 CRC patients (30 male and 19 female, median age 66 years) who underwent PM between January 2008 and December 2015 were retrospectively analyzed. Results STAS was identified in 26.5% ( n = 13) of resected specimens. Location of pulmonary lesions (central vs. peripheral) was assessed based on the available computed tomography imaging ( n = 47, 96%). STAS was detected in all five patients with central metastases (100%) versus 7 of 42 (17%) with peripheral metastases ( p = 0.0001). Locoregional recurrence occurred in STAS-positive patients ( n = 4 of 13 vs. n = 0 of 36), all STAS-negative patients remained recurrence-free ( p = 0.003). Median number of alveoli with STAS involvement was four (range from 2 to 9). There was statistically positive relationship between the number of alveoli invaded with STAS and locoregional recurrence of metastases ( p = 0.0001). The presence of STAS is not a factor affecting the 5-year overall survival rate ( p = 0.6651). Conclusion We identified STAS as a frequent finding in resected CRC lung metastases and found insignificant association with outcome. Georg Thieme Verlag KG 2022-10-18 /pmc/articles/PMC9998148/ /pubmed/36257546 http://dx.doi.org/10.1055/s-0042-1757632 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Haj Khalaf, Mohamed Anwar Sirbu, Horia Hartmann, Arndt Agaimy, Abbas Dudek, Wojciech Higaze, Mostafa Rieker, Ralf Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title | Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title_full | Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title_fullStr | Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title_full_unstemmed | Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title_short | Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC) |
title_sort | spread through air spaces (stas) in solitary pulmonary metastases from colorectal cancer (crc) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998148/ https://www.ncbi.nlm.nih.gov/pubmed/36257546 http://dx.doi.org/10.1055/s-0042-1757632 |
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