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Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion

The aim of this study was to evaluate efficacies of selected lactic acid bacteria (LAB) in inducing immunoglobulin A (IgA) secretion. Twenty-five different LAB isolated from traditional fermented Korean foods were characterized for their probiotic properties and screened to identify those that could...

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Autores principales: Choi, Chang-Yong, Lee, Chang-Hee, Yang, Jun, Kang, Seok-Jin, Park, In-Byung, Park, Si-Won, Lee, Na-Young, Hwang, Hyun-Been, Yun, Hyun Sun, Chun, Taehoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Food Science of Animal Resources 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998188/
https://www.ncbi.nlm.nih.gov/pubmed/36909859
http://dx.doi.org/10.5851/kosfa.2023.e2
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author Choi, Chang-Yong
Lee, Chang-Hee
Yang, Jun
Kang, Seok-Jin
Park, In-Byung
Park, Si-Won
Lee, Na-Young
Hwang, Hyun-Been
Yun, Hyun Sun
Chun, Taehoon
author_facet Choi, Chang-Yong
Lee, Chang-Hee
Yang, Jun
Kang, Seok-Jin
Park, In-Byung
Park, Si-Won
Lee, Na-Young
Hwang, Hyun-Been
Yun, Hyun Sun
Chun, Taehoon
author_sort Choi, Chang-Yong
collection PubMed
description The aim of this study was to evaluate efficacies of selected lactic acid bacteria (LAB) in inducing immunoglobulin A (IgA) secretion. Twenty-five different LAB isolated from traditional fermented Korean foods were characterized for their probiotic properties and screened to identify those that could stimulate lamina propria cells (LPCs) from Peyer’s patch to secret IgA in vitro. Among them, four strains (Lactiplantibacillus plantarum CJW55-10, Lactiplantibacillus pentosus CJW18-6, L. pentosus CJW56-11, and Pediococcus acidilactici CJN2696) were found to be strong IgA inducers. The number of IgA positive B cells and soluble IgA level were increased when LPCs were co-cultured with these LAB. Expression levels of toll-like receptor (TLR) such as TLR2 and TLR4 and secretion of interleuckin-6 were augmented in LPCs treated with these LAB. Further, we determined whether oral intake of these LAB enhanced IgA production in vivo. After one-week of daily oral administration, these LAB feed mice increased mucosal IgA and serum IgA. In conclusion, selected strains of LAB could induce systemic IgA secretion by activating lamina propria B cells in Peyer’s patch and oral intake of selected strains of LAB can enhance systemic immunity by inducing mucosal IgA secretion.
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spelling pubmed-99981882023-03-10 Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion Choi, Chang-Yong Lee, Chang-Hee Yang, Jun Kang, Seok-Jin Park, In-Byung Park, Si-Won Lee, Na-Young Hwang, Hyun-Been Yun, Hyun Sun Chun, Taehoon Food Sci Anim Resour Article The aim of this study was to evaluate efficacies of selected lactic acid bacteria (LAB) in inducing immunoglobulin A (IgA) secretion. Twenty-five different LAB isolated from traditional fermented Korean foods were characterized for their probiotic properties and screened to identify those that could stimulate lamina propria cells (LPCs) from Peyer’s patch to secret IgA in vitro. Among them, four strains (Lactiplantibacillus plantarum CJW55-10, Lactiplantibacillus pentosus CJW18-6, L. pentosus CJW56-11, and Pediococcus acidilactici CJN2696) were found to be strong IgA inducers. The number of IgA positive B cells and soluble IgA level were increased when LPCs were co-cultured with these LAB. Expression levels of toll-like receptor (TLR) such as TLR2 and TLR4 and secretion of interleuckin-6 were augmented in LPCs treated with these LAB. Further, we determined whether oral intake of these LAB enhanced IgA production in vivo. After one-week of daily oral administration, these LAB feed mice increased mucosal IgA and serum IgA. In conclusion, selected strains of LAB could induce systemic IgA secretion by activating lamina propria B cells in Peyer’s patch and oral intake of selected strains of LAB can enhance systemic immunity by inducing mucosal IgA secretion. Korean Society for Food Science of Animal Resources 2023-03 2023-03-01 /pmc/articles/PMC9998188/ /pubmed/36909859 http://dx.doi.org/10.5851/kosfa.2023.e2 Text en © Korean Society for Food Science of Animal Resources https://creativecommons.org/licenses/by-nc/3.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Choi, Chang-Yong
Lee, Chang-Hee
Yang, Jun
Kang, Seok-Jin
Park, In-Byung
Park, Si-Won
Lee, Na-Young
Hwang, Hyun-Been
Yun, Hyun Sun
Chun, Taehoon
Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title_full Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title_fullStr Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title_full_unstemmed Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title_short Efficacies of Potential Probiotic Candidates Isolated from Traditional Fermented Korean Foods in Stimulating Immunoglobulin A Secretion
title_sort efficacies of potential probiotic candidates isolated from traditional fermented korean foods in stimulating immunoglobulin a secretion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998188/
https://www.ncbi.nlm.nih.gov/pubmed/36909859
http://dx.doi.org/10.5851/kosfa.2023.e2
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