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Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by fibrosis that develops from fatty liver. Disruption of intestinal microbiota homeostasis, dysbiosis, is associated with fibrosis development in NASH. An antimicrobial peptide α-defensin secreted by Paneth cells in the sm...

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Detalles Bibliográficos
Autores principales:	Nakamura, Shunta, Nakamura, Kiminori, Yokoi, Yuki, Shimizu, Yu, Ohira, Shuya, Hagiwara, Mizu, Song, Zihao, Gan, Li, Aizawa, Tomoyasu, Hashimoto, Daigo, Teshima, Takanori, Ouellette, Andre J., Ayabe, Tokiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998432/ https://www.ncbi.nlm.nih.gov/pubmed/36894646 http://dx.doi.org/10.1038/s41598-023-30997-y

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