YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression

YgfB-mediated β-lactam resistance was recently identified in multi drug resistant Pseudomonas aeruginosa. We show that YgfB upregulates expression of the β-lactamase AmpC by repressing the function of the regulator of the programmed cell death pathway AlpA. In response to DNA damage, the antitermina...

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Detalles Bibliográficos
Autores principales: Eggers, Ole, Renschler, Fabian A., Michalek, Lydia Anita, Wackler, Noelle, Walter, Elias, Smollich, Fabian, Klein, Kristina, Sonnabend, Michael S., Egle, Valentin, Angelov, Angel, Engesser, Christina, Borisova, Marina, Mayer, Christoph, Schütz, Monika, Bohn, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998450/
https://www.ncbi.nlm.nih.gov/pubmed/36894667
http://dx.doi.org/10.1038/s42003-023-04609-4

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