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Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial
Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998473/ https://www.ncbi.nlm.nih.gov/pubmed/36908662 http://dx.doi.org/10.1016/j.jacbts.2022.08.009 |
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| author | Taqueti, Viviany R. Shah, Amil M. Everett, Brendan M. Pradhan, Aruna D. Piazza, Gregory Bibbo, Courtney Hainer, Jon Morgan, Victoria Carolina do A. H. de Souza, Ana Skali, Hicham Blankstein, Ron Dorbala, Sharmila Goldhaber, Samuel Z. Le May, Michel R. Chow, Benjamin J.W. deKemp, Robert A. Hage, Fadi G. Beanlands, Rob S. Libby, Peter Glynn, Robert J. Solomon, Scott D. Ridker, Paul M. Di Carli, Marcelo F. |
| author_facet | Taqueti, Viviany R. Shah, Amil M. Everett, Brendan M. Pradhan, Aruna D. Piazza, Gregory Bibbo, Courtney Hainer, Jon Morgan, Victoria Carolina do A. H. de Souza, Ana Skali, Hicham Blankstein, Ron Dorbala, Sharmila Goldhaber, Samuel Z. Le May, Michel R. Chow, Benjamin J.W. deKemp, Robert A. Hage, Fadi G. Beanlands, Rob S. Libby, Peter Glynn, Robert J. Solomon, Scott D. Ridker, Paul M. Di Carli, Marcelo F. |
| author_sort | Taqueti, Viviany R. |
| collection | PubMed |
| description | Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease. (Cardiovascular Inflammation Reduction Trial [CIRT]; NCT01594333; Coronary Flow Reserve to Assess Cardiovascular Inflammation [CIRT-CFR]; NCT02786134) |
| format | Online Article Text |
| id | pubmed-9998473 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99984732023-03-11 Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial Taqueti, Viviany R. Shah, Amil M. Everett, Brendan M. Pradhan, Aruna D. Piazza, Gregory Bibbo, Courtney Hainer, Jon Morgan, Victoria Carolina do A. H. de Souza, Ana Skali, Hicham Blankstein, Ron Dorbala, Sharmila Goldhaber, Samuel Z. Le May, Michel R. Chow, Benjamin J.W. deKemp, Robert A. Hage, Fadi G. Beanlands, Rob S. Libby, Peter Glynn, Robert J. Solomon, Scott D. Ridker, Paul M. Di Carli, Marcelo F. JACC Basic Transl Sci Original Research - Clinical Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease. (Cardiovascular Inflammation Reduction Trial [CIRT]; NCT01594333; Coronary Flow Reserve to Assess Cardiovascular Inflammation [CIRT-CFR]; NCT02786134) Elsevier 2022-12-21 /pmc/articles/PMC9998473/ /pubmed/36908662 http://dx.doi.org/10.1016/j.jacbts.2022.08.009 Text en © 2022 Published by Elsevier on behalf of the American College of Cardiology Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Original Research - Clinical Taqueti, Viviany R. Shah, Amil M. Everett, Brendan M. Pradhan, Aruna D. Piazza, Gregory Bibbo, Courtney Hainer, Jon Morgan, Victoria Carolina do A. H. de Souza, Ana Skali, Hicham Blankstein, Ron Dorbala, Sharmila Goldhaber, Samuel Z. Le May, Michel R. Chow, Benjamin J.W. deKemp, Robert A. Hage, Fadi G. Beanlands, Rob S. Libby, Peter Glynn, Robert J. Solomon, Scott D. Ridker, Paul M. Di Carli, Marcelo F. Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title | Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title_full | Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title_fullStr | Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title_full_unstemmed | Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title_short | Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial |
| title_sort | coronary flow reserve, inflammation, and myocardial strain: the cirt-cfr trial |
| topic | Original Research - Clinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998473/ https://www.ncbi.nlm.nih.gov/pubmed/36908662 http://dx.doi.org/10.1016/j.jacbts.2022.08.009 |
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